SCHEMBL2940438

SCHEMBL2940438

c1cc2[nH]ncc2c2c1CCCN2

nearest known ligand 0.46

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
NOS1 P29475 4/20 0.36
AXL P30530 2/20 0.36
CDK2 P24941 7/20 0.35
CCNA1 P78396 7/20 0.35
FLT3 P36888 6/20 0.35
STING1 Q86WV6 1/20 0.35
IDO1 P14902 1/20 0.34
KDR P35968 1/20 0.34
MAPK10 P53779 1/20 0.34
RIPK1 Q13546 1/20 0.34
SRC P12931 1/20 0.34
PARP1 P09874 1/20 0.33
TNK1 Q13470 1/20 0.33
METAP2 P50579 1/20 0.33
PBK Q96KB5 1/20 0.32
CCNA2 P20248 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3004803 0.75 NOS1 (0.40) NOS1AXLCDK2CCNA1IDO1
SCHEMBL19511770 0.73 SRC (0.46) SRC
SCHEMBL20002212 0.72 CDK2 (0.47) NOS1AXLCDK2CCNA1FLT3
SCHEMBL180561 0.72 HTR1D (0.39) SRCPARP1TNK1
SCHEMBL3201541 0.71 TRPV1 (0.34) NOS1AXLCDK2CCNA1FLT3
SCHEMBL27139628 0.69 MAPT (0.37) NOS1FLT3KDRSRCPARP1
SCHEMBL19118540 0.69 IDO1 (0.40) NOS1AXLCDK2CCNA1FLT3
SCHEMBL12321248 0.69 NOS1 (0.56) NOS1AXLCDK2CCNA1IDO1
SCHEMBL31712925 0.68 SRC (0.33) SRC
SCHEMBL6725176 0.67 CXCR4 (0.40) SRC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 133 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10071156-B2 Aqueous gel formulations containing immune response modifiers 3M INNOVATIVE PROPERTIES COMPANY (US) 2018-09-11 US claimed
US-20160101173-A1 AQUEOUS GEL FORMULATIONS CONTAINING IMMUNE RESPONSE MODIFIERS 3M INNOVATIVE PROPERTIES CO (US) 2016-04-14 US claimed
US-9248127-B2 Aqueous gel formulations containing immune response modifiers 3M INNOVATIVE PROPERTIES COMPANY (US) 2016-02-02 US claimed
US-20090163532-A1 Aqueous Gel Formulations Containing Immune Response Modifiers COLEY PHARMACEUTICAL GROUP, INC. (US) 2009-06-25 US claimed
EP-1844201-A2 AQUEOUS GEL FORMULATIONS CONTAINING IMMUNE RESPONSE MODIFIERS 3M INNOVATIVE PROPERTIES COMPANY (US) 2007-10-17 EP claimed
WO-2006084251-A2 AQUEOUS GEL FORMULATIONS CONTAINING IMMUNE REPONSE MODIFIERS COLEY PHARMACEUTICAL GROUP, INC. (US) 2006-08-10 WO claimed
US-20240173390-A1 PEPTIDE VACCINE FORMULATIONS AND USE THEREOF FOR INDUCING AN IMMUNE RESPONSE THE U.S.A, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2024-05-30 US disclosed
CN-118103059-A Self-assembled nanoparticles based on amphiphilic peptides 巴林萨斯生物疗法北美公司 2024-05-28 CN disclosed
WO-2024092030-A1 SELF-ASSEMBLING NANOPARTICLES VACCITECH NORTH AMERICA, INC. (US) 2024-05-02 WO disclosed
WO-2024092028-A2 COMBINATION TREATMENT REGIMES FOR TREATING CANCER VACCITECH NORTH AMERICA, INC. (US) 2024-05-02 WO disclosed
EP-4355367-A1 SELF-ASSEMBLING NANOPARTICLES BASED ON AMPHIPHILIC PEPTIDES FOR DRUG DELIVERY APPLICATIONS Barinthus Biotherapeutics North America, Inc. (US) 2024-04-24 EP disclosed
US-11938177-B2 Peptide vaccine formulations and use thereof for inducing an immune response THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2024-03-26 US disclosed
EP-4294431-A1 SELF-ASSEMBLING NANOPARTICLES BASED ON AMPHIPHILIC PEPTIDES Vaccitech North America, Inc. (US) 2023-12-27 EP disclosed
US-20060045885-A1 Method of eliciting an immune response against HIV GOVERNMENT OF THE UNITED STRATS OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES, THE 2006-03-02 US disclosed
US-20060045886-A1 HIV immunostimulatory compositions 3M INNOVATIVE PROPERTIES COMPANY 2006-03-02 US disclosed
WO-2006007491-A1 MITOTIC KINESIN INHIBITORS MERCK & CO., INC. (US) 2006-01-19 WO disclosed
US-20050267145-A1 Treatment for lung cancer COLEY PHARMACEUTICAL GROUP, INC. 2005-12-01 US disclosed
US-20050226878-A1 Therapeutic combinations and methods including IRM compounds 3M INNOVATIVE PROPERTIES COMPANY 2005-10-13 US disclosed
EP-0506709-A1 ARTHROPODICIDAL PYRAZOLINES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1992-10-07 EP disclosed
WO-1991008207-A1 ARTHROPODICIDAL PYRAZOLINES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1991-06-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240173390-A1 PEPTIDE VACCINE FORMULATIONS AND USE THEREOF FOR INDUCING AN IMMUNE RESPONSE NGLY1, MYD88, SPPL2B NOS1 3307/4885AXL 1492/4885CDK2 4452/4885
US-20060045886-A1 HIV immunostimulatory compositions CD4, ICOS, CXCL10 NOS1 2672/4885AXL 2372/4885CDK2 4620/4885
US-10071156-B2 Aqueous gel formulations containing immune response modifiers IFNG, ICOS, IL4 NOS1 405/4885AXL 1108/4885CDK2 838/4885
US-11938177-B2 Peptide vaccine formulations and use thereof for inducing an immune response NGLY1, MYD88, SPPL2B NOS1 3307/4885AXL 1492/4885CDK2 4452/4885
US-20090163532-A1 Aqueous Gel Formulations Containing Immune Response Modifiers IFNG, ICOS, IL4 NOS1 405/4885AXL 1108/4885CDK2 838/4885
US-20160101173-A1 AQUEOUS GEL FORMULATIONS CONTAINING IMMUNE RESPONSE MODIFIERS IFNG, ICOS, IL4 NOS1 405/4885AXL 1108/4885CDK2 838/4885
US-20060045885-A1 Method of eliciting an immune response against HIV CD69, IRF3, CD4 NOS1 3183/4885AXL 4538/4885CDK2 4850/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.