Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 12/20 | 0.69 |
| ▸ | INSR | P06213 | 8/20 | 0.69 |
| ▸ | ALK | Q9UM73 | 13/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2945450 | 0.95 | MET (0.67) | METINSRALKEGFR | |
| SCHEMBL2942941 | 0.92 | MET (0.68) | METINSRALKEGFR | |
| SCHEMBL2062201 | 0.91 | INSR (0.64) | METINSRALKEGFR | |
| SCHEMBL2940464 | 0.91 | MET (0.83) | METINSRALKEGFR | |
| SCHEMBL886364 | 0.91 | MET (0.83) | METINSRALKEGFR | |
| SCHEMBL886031 | 0.87 | MET (0.78) | METINSRALKEGFR | |
| SCHEMBL2060439 | 0.87 | INSR (0.66) | METINSRALKEGFR | |
| SCHEMBL2945452 | 0.87 | MET (0.77) | METINSRALKEGFR | |
| SCHEMBL886613 | 0.87 | MET (0.77) | METINSRALKEGFR | |
| SCHEMBL2060292 | 0.87 | INSR (0.62) | METINSRALKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |