Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.42 |
| ▸ | ORAI1 | Q96D31 | 3/20 | 0.41 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.41 |
| ▸ | BRAF | P15056 | 4/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.39 |
| ▸ | WNT1 | P04628 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | KCNT1 | Q5JUK3 | 4/20 | 0.39 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | KCNMB1 | Q16558 | 1/20 | 0.38 |
| ▸ | KCNT2 | Q6UVM3 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22659319 | 1.00 | HPGDS (0.42) | HPGDSORAI1STIM1NTRK1BRAF | |
| SCHEMBL22658921 | 0.91 | STIM1 (0.41) | HPGDSORAI1STIM1NTRK1BRAF | |
| SCHEMBL24571337 | 0.91 | SCN9A (0.45) | HPGDSORAI1STIM1NTRK1TRPM8 | |
| SCHEMBL24571213 | 0.90 | NTRK1 (0.47) | HPGDSORAI1STIM1NTRK1BRAF | |
| SCHEMBL29406420 | 0.90 | NTRK1 (0.47) | HPGDSORAI1STIM1NTRK1BRAF | |
| SCHEMBL24571216 | 0.89 | KCNT1 (0.46) | HPGDSORAI1STIM1NTRK1BRAF | |
| SCHEMBL22659907 | 0.89 | TRPV1 (0.43) | HPGDSORAI1STIM1NTRK1BRAF | |
| SCHEMBL22659854 | 0.89 | KCNT1 (0.48) | NTRK1BRAFDYRK1AIGF1RKCNT1 | |
| SCHEMBL29403796 | 0.89 | KCNT1 (0.48) | NTRK1BRAFDYRK1AIGF1RKCNT1 | |
| SCHEMBL24571339 | 0.87 | HPGDS (0.46) | HPGDSORAI1STIM1NTRK1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3966208-A2 | COMPOUNDS AND METHODS FOR TREATING CANCER | Antidote IP Holdings, LLC (US) | 2022-03-16 | — | — | EP | disclosed |