Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 3/20 | 0.33 |
| ▸ | NOS3 | P29474 | 2/20 | 0.33 |
| ▸ | NOS1 | P29475 | 2/20 | 0.33 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.32 |
| ▸ | NAALAD2 | Q9Y3Q0 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | RIMKLA | Q8IXN7 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | THPO | P40225 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | LAP3 | P28838 | 2/20 | 0.32 |
| ▸ | GGH | Q92820 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2940610 | 1.00 | NOS2 (0.33) | NOS2NOS3NOS1FOLH1NAALAD2 | |
| SCHEMBL24633945 | 0.83 | FOLH1 (0.34) | FOLH1NAALAD2MAPTRIMKLAKDM4E | |
| SCHEMBL31754331 | 0.83 | FOLH1 (0.34) | FOLH1NAALAD2MAPTRIMKLAKDM4E | |
| SCHEMBL21192393 | 0.81 | GABRP (0.46) | FOLH1NAALAD2LAP3 | |
| SCHEMBL18095151 | 0.76 | — | — | |
| SCHEMBL10122856 | 0.76 | — | — | |
| SCHEMBL29657364 | 0.76 | ALDH1A1 (0.43) | FOLH1NAALAD2MAPTRIMKLAKDM4E | |
| SCHEMBL21635774 | 0.76 | ALDH1A1 (0.43) | FOLH1NAALAD2MAPTRIMKLAKDM4E | |
| SCHEMBL29805658 | 0.76 | — | — | |
| SCHEMBL882883 | 0.76 | ALDH1A1 (0.43) | FOLH1NAALAD2MAPTRIMKLAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8673594-B2 | Methods for stimulating nervous system regeneration and repair by regulating arginase I and polyamine synthesis | RESEARCH FOUNDATION OF CITY UNIVERSITY OF NEW YORK (US) | 2014-03-18 | — | — | US | disclosed |
| US-20100216710-A1 | METHODS FOR STIMULATING NERVOUS SYSTEM REGENERATION AND REPAIR BY REGULATING ARGINASE I AND POLYAMINE SYNTHESIS | RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK (US) | 2010-08-26 | — | — | US | disclosed |
| US-7741310-B2 | Methods for stimulating nervous system regeneration and repair by regulating arginase I and polyamine synthesis | RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK (US) | 2010-06-22 | — | — | US | disclosed |
| EP-1278537-B1 | COMPOSITIONS FOR STIMULATING NERVOUS SYSTEM REGENERATION AND REPAIR BY REGULATING ARGINASE I AND POLYAMINE SYNTHESIS | UNIV CITY (US) | 2009-01-14 | — | — | EP | disclosed |
| US-20030215428-A1 | A polynucleotide encodes an arginase, a nerve growth factors for treating nervous system disorders, neurodegenerative diseases | RESEARCH FOUNDATION OF CITY UNIVERSITY OF NEW YORK | 2003-11-20 | — | — | US | disclosed |
| EP-1278537-A2 | METHODS FOR STIMULATING NERVOUS SYSTEM REGENERATION AND REPAIR BY REGULATING ARGINASE I AND POLYAMINE SYNTHESIS | The Research Foundation of the City University of New York (US) | 2003-01-29 | — | — | EP | disclosed |
| WO-2001085981-A2 | METHODS FOR STIMULATING NERVOUS SYSTEM REGENERATION AND REPAIR BY REGULATING ARGINASE I AND POLYAMINE SYNTHESIS | RESEARCH FOUNDATION OF CITY UNIVERSITY OF NEW YORK (US) | 2001-11-15 | — | — | WO | disclosed |