SCHEMBL2940720

SCHEMBL2940720

CC(Oc1cnccc1CN1C(=O)N(c2ccc(OC(F)(F)F)cc2)C(=O)C1(C)C)N1CCCC1

nearest known ligand 0.42

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
IGF1R P08069 13/20 0.42
TAS2R8 Q9NYW2 4/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2933710 0.87 IGF1R (0.55) IGF1RTAS2R8
SCHEMBL2942365 0.84 IGF1R (0.48) IGF1RTAS2R8
SCHEMBL2940721 0.84 IGF1R (0.42) IGF1R
SCHEMBL2939828 0.83 TAS2R8 (0.35) TAS2R8
SCHEMBL2941008 0.83 IGF1R (0.47) IGF1R
SCHEMBL2942599 0.82 IGF1R (0.45) IGF1R
SCHEMBL2941133 0.82 IGF1R (0.40) IGF1R
SCHEMBL2939070 0.82 IGF1R (0.48) IGF1R
SCHEMBL2942344 0.81 IGF1R (0.47) IGF1R
SCHEMBL2937664 0.81 IGF1R (0.47) IGF1RTAS2R8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1599464-B1 NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS AVENTIS PHARMA SA (FR) 2010-09-22 EP disclosed