Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10690540 | 0.92 | KMT2A (0.48) | MEN1KMT2ATSHRCYP2C19CYP1A2 | |
| SCHEMBL5968140 | 0.82 | KMT2A (0.36) | MEN1KMT2ATSHRSMN1; SMN2NPC1 | |
| SCHEMBL26657 | 0.81 | PLAAT5 (0.53) | SMN1; SMN2MAPTALDH1A1FFAR1TDP1 | |
| SCHEMBL5968137 | 0.79 | ALDH1A1 (0.36) | MEN1KMT2ASMN1; SMN2RAB9AMAPT | |
| SCHEMBL350869 | 0.77 | TSHR (0.63) | MEN1KMT2ATSHRCYP2C19CYP1A2 | |
| SCHEMBL8749106 | 0.76 | ALDH1A1 (0.46) | ALDH1A1L3MBTL1FFAR1TDP1 | |
| SCHEMBL7999122 | 0.76 | TSHR (0.66) | MEN1KMT2ATSHRCYP2C19CYP1A2 | |
| SCHEMBL1628272 | 0.75 | TSHR (0.56) | MEN1KMT2ATSHRCYP2C19CYP1A2 | |
| SCHEMBL8748832 | 0.74 | KEAP1 (0.55) | SMN1; SMN2MAPTALDH1A1FFAR1TDP1 | |
| SCHEMBL15074911 | 0.73 | TSHR (0.61) | MEN1KMT2ATSHRCYP2C19CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200339582-A1 | Atypical Carbapenem Antibiotics with Improved Activity Against Carbapenemase-Producing Acinetobacter baumannii | BUYNAK JOHN (US) | 2020-10-29 | — | — | US | disclosed |
| EP-1670806-B9 | PROCESS FOR PREPARATION OF ESTERS OF 2-DIAZO-3-TRIMETHYLSILYLOXY-3-BUTENOIC ACID | RANBAXY LAB LTD (IN) | 2010-06-02 | — | — | EP | disclosed |
| EP-1670806-B1 | PROCESS FOR PREPARATION OF ESTERS OF 2-DIAZO-3-TRIMETHYLSILYLOXY-3-BUTENOIC ACID | RANBAXY LAB LTD (IN) | 2010-01-06 | — | — | EP | disclosed |
| US-5340927-A | Process for the preparation of 2-diazo-3-trisubstituted silyloxy 3-butenoates | MERCK & CO., INC. (US) | 1994-08-23 | — | — | US | disclosed |
| EP-0409331-A2 | A novel process for the preparation of 2-diazo-3-trisubstituted silyloxy-3-butenoates | MERCK & CO. INC. (US) | 1991-01-23 | — | — | EP | disclosed |
| EP-0247431-B1 | SUBSTITUTED 6-HYDROXYMETHYLCARBAPENEM ANTIBIOTICS, PROCESS FOR THEIR PREPARATION AND THEIR USE | BAYER AG (DE) | 1990-08-01 | — | — | EP | disclosed |
| US-4841042-A | Process for the preparation of carbapenem intermediates | BAYER AKTIENGESELLSCHAFT (DE) | 1989-06-20 | — | — | US | disclosed |
| EP-0247431-A1 | Substituted 6-hydroxymethylcarbapenem antibiotics, process for their preparation and their use | BAYER AG (DE) | 1987-12-02 | — | — | EP | disclosed |
| EP-0195963-A1 | Process for the preparation of carbapenem intermediates | BAYER AG (DE) | 1986-10-01 | — | — | EP | disclosed |