Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTRC | Q99895 | 2/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.44 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
| ▸ | MIF | P14174 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22658051 | 1.00 | CTRC (0.48) | CTRCMCL1SCN9APTGER4KDM4E | |
| SCHEMBL29408125 | 0.87 | SCN9A (0.45) | CTRCSCN9AKDM4EMAPK1MEN1 | |
| SCHEMBL22658101 | 0.87 | SCN9A (0.45) | CTRCSCN9AKDM4EMAPK1MEN1 | |
| SCHEMBL14919880 | 0.81 | SCN9A (0.64) | MCL1SCN9A | |
| SCHEMBL22678577 | 0.80 | NPSR1 (0.45) | MCL1KDM4EMAPK1MEN1POLB | |
| SCHEMBL16706636 | 0.79 | CTRC (0.66) | CTRCMCL1KDM4EMEN1KMT2A | |
| SCHEMBL22678524 | 0.78 | MCL1 (0.47) | MCL1SCN9APTGER4MRGPRX4GRM2 | |
| SCHEMBL29408290 | 0.78 | MCL1 (0.47) | MCL1SCN9APTGER4MRGPRX4GRM2 | |
| SCHEMBL20346112 | 0.78 | CTRC (0.61) | CTRCMCL1PTGER4KDM4EMEN1 | |
| SCHEMBL16710006 | 0.76 | ADORA3 (0.52) | CTRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3969439-A1 | ACSS2 INHIBITORS AND METHODS OF USE THEREOF | Metabomed Ltd (IL) | 2022-03-23 | — | — | EP | disclosed |
| CN-114127049-A | ACSS2 inhibitors and methods of use thereof | 美特波米德有限公司 | 2022-03-01 | — | — | CN | disclosed |