Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.32 |
| ▸ | GRM5 | P41594 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22612357 | 1.00 | TIPARP (0.33) | TIPARPMAPK1SCN9AGRM5 | |
| SCHEMBL22612360 | 1.00 | TIPARP (0.33) | TIPARPMAPK1SCN9AGRM5 | |
| SCHEMBL22612368 | 0.82 | TIPARP (0.34) | TIPARPSCN9AGRM5 | |
| SCHEMBL22612370 | 0.82 | TIPARP (0.34) | TIPARPSCN9AGRM5 | |
| SCHEMBL31566196 | 0.82 | TIPARP (0.34) | TIPARPSCN9AGRM5 | |
| SCHEMBL22612355 | 0.82 | GRM5 (0.37) | MAPK1SCN9AGRM5 | |
| SCHEMBL22612358 | 0.82 | GRM5 (0.37) | MAPK1SCN9AGRM5 | |
| SCHEMBL22616381 | 0.77 | TIPARP (0.32) | TIPARP | |
| SCHEMBL22622952 | 0.73 | ALDH1A1 (0.45) | — | |
| SCHEMBL10801442 | 0.61 | MAPK1 (0.39) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4237413-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | Calico Life Sciences LLC (US) | 2023-09-06 | — | — | EP | disclosed |
| WO-2022094244-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2022-05-05 | — | — | WO | disclosed |
| EP-3962906-A1 | SUBSTITUTED CYCLOALKYLS AS MODULATORS OF THE INTEGRATED STRESS PATHWAY | Calico Life Sciences LLC (US) | 2022-03-09 | — | — | EP | disclosed |