Flubendazole

Flubendazole

SCHEMBL29409278

COC(=O)Nc1nc2cc(C(=O)c3ccc(F)cc3)ccc2[nH]1

nearest known ligand 0.82

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDR P35968 3/20 0.82
MAPK1 P28482 2/20 0.82
ADORA3 P0DMS8 1/20 0.82
PTGS1 P23219 1/20 0.82
RXFP1 Q9HBX9 1/20 0.82
LMNA P02545 4/20 0.65
CYP1A2 P05177 4/20 0.65
HIF1A Q16665 4/20 0.65
ALDH1A1 P00352 2/20 0.65
ABL1 P00519 2/20 0.65
CYP2C9 P11712 2/20 0.65
HTT P42858 2/20 0.65
ABCC4 O15439 1/20 0.65
USP2 O75604 1/20 0.65
TUBB4A P04350 4/20 0.54
TUBB P07437 4/20 0.54
TUBA3C P0DPH7 4/20 0.54
TUBA1B P68363 4/20 0.54
TUBA4A P68366 4/20 0.54
TUBB4B P68371 4/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Flubendazole SCHEMBL167185 1.00 KDR (0.82) KDRMAPK1ADORA3PTGS1RXFP1
Flubendazole SCHEMBL22321861 0.99 KDR (0.80) KDRMAPK1ADORA3PTGS1RXFP1
Flubendazole SCHEMBL8005889 0.95 KDR (0.76) KDRMAPK1ADORA3PTGS1RXFP1
Flubendazole SCHEMBL28005737 0.95 KDR (0.76) KDRMAPK1ADORA3PTGS1RXFP1
Flubendazole SCHEMBL453978 0.94 KDR (0.78) KDRMAPK1ADORA3PTGS1RXFP1
Flubendazole SCHEMBL20815724 0.91 KDR (0.69) KDRMAPK1ADORA3PTGS1RXFP1
Flubendazole SCHEMBL31704404 0.90 KDR (1.00) KDRMAPK1ADORA3PTGS1RXFP1
Flubendazole SCHEMBL6232065 0.90 KDR (1.00) KDRMAPK1ADORA3PTGS1RXFP1
Mebendazole SCHEMBL15860 0.89 ABL1 (0.82) KDRMAPK1ADORA3PTGS1RXFP1
Mebendazole SCHEMBL3429179 0.89 ABL1 (0.82) KDRMAPK1ADORA3PTGS1RXFP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250295787-A1 PRESERVED ETHERIFIED CYCLODEXTRIN DERIVATIVES CONTAINING LIQUID AQUEOUS PHARMACEUTICAL COMPOSITION BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) 2025-09-25 US claimed
EP-4389116-B1 PHARMACEUTICAL AQUEOUS FLUBENDAZOLE SUSPENSION DECHRA LTD (GB) 2025-09-10 EP claimed
EP-3965808-B1 USE OF PARASITES AND EXTRACELLULAR VESICLES OBTAINED FROM PARASITES IN CANCER TREATMENT UNIV YEDITEPE (TR) 2025-09-03 EP claimed
EP-4140504-B1 MICELLE MADE FROM BENZIMIDAZOLE-CARBOHYDRATE CONJUGATE COMPOUND, PREPARATION METHOD THEREOF AND USE THEREOF AS ANTICANCER AGENT OR ANTIVIRAL AGENT COMPRISING THE SAME BIOMETRIX TECH INC (KR) 2025-01-15 EP claimed
EP-3907230-B1 NOVEL BENZIMIDAZOLE DERIVATIVES, PREPARATION METHOD THEREOF AND USE THEREOF AS ANTI-CANCER AGENT COMPRISING THE SAME BIOMETRIX TECH INC (KR) 2024-08-28 EP claimed
WO-2024102612-A1 COMPOUNDS AND METHODS FOR IDENTIFYING COMPOUNDS FOR MODULATING GLUCOSE TRANSPORT THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2024-05-16 WO claimed
US-11725227-B2 Devices and methods for examining drug effects on microorganisms ESSENLIX CORPORATION (US) 2023-08-15 US claimed
EP-3021832-B9 PRESERVED ETHERIFIED CYCLODEXTRIN DERIVATIVES CONTAINING LIQUID AQUEOUS PHARMACEUTICAL COMPOSITION BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) 2023-03-15 EP claimed
EP-3972591-B1 PHARMACEUTICAL COMPOSITIONS COMPRISING FLUBENDAZOLE ZEPHAPHARM LTD (GB) 2022-12-28 EP claimed
CN-114903046-A Bactericidal composition and application thereof 沈阳中化农药化工研发有限公司 2022-08-16 CN claimed
EP-3448435-B1 PROTEIN BASED EXCIPIENT FOR ACTIVE PHARMACEUTICAL INGREDIENTS ROUSSELOT B V (NL) 2022-06-01 EP claimed
EP-3599855-B1 DELAYED RELEASE FEED-THROUGH VETERINARY COMPOSITIONS WITH OVICIDAL AND LARVICIDAL ACTIVITY AGAINST SUSCEPTIBLE AND RESISTANT STRAINS OF PARASITES IN RUMINANTS' FECES, USE OF THESE COMPOSITIONS, METHOD FOR DELAYING THE RELEASE OF THESE COMPOSITIONS Champion USA LLC (US) 2022-03-02 EP claimed
US-12582717-B2 Protein based excipient for active pharmaceutical ingredients DISPERSOME IP APS (NL) 2026-03-24 US disclosed
US-20250295787-A1 PRESERVED ETHERIFIED CYCLODEXTRIN DERIVATIVES CONTAINING LIQUID AQUEOUS PHARMACEUTICAL COMPOSITION BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) 2025-09-25 US disclosed
US-12357696-B2 Preserved etherified cyclodextrin derivatives containing liquid aqueous pharmaceutical composition BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) 2025-07-15 US disclosed
EP-3865120-B1 PRESERVED ETHERIFIED CYCLODEXTRIN DERIVATIVES CONTAINING LIQUID AQUEOUS PHARMACEUTICAL COMPOSITION BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) 2025-06-25 EP disclosed
EP-3974414-A1 5-AMINO SUBSTITUTED PYRAZOLES AND TRIAZOLES AS PESTICIDES Bayer AG (DE) 2022-03-30 EP disclosed
EP-3972591-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING FLUBENDAZOLE Zephapharm Ltd. (GB) 2022-03-30 EP disclosed
WO-2022053453-A1 AZOLE CARBOXAMIDE AS PEST CONTROL AGENTS BAYER AKTIENGESELLSCHAFT (DE) 2022-03-17 WO disclosed
US-20220072136-A1 PROTEIN BASED EXCIPIENT FOR ACTIVE PHARMACEUTICAL INGREDIENTS DISPERSOME IP APS (NL) 2022-03-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12357696-B2 Preserved etherified cyclodextrin derivatives containing liquid aqueous pharmaceutical composition SI, PIM1, PIM3 KDR 2227/4885MAPK1 2653/4885ADORA3 3352/4885
US-20250295787-A1 PRESERVED ETHERIFIED CYCLODEXTRIN DERIVATIVES CONTAINING LIQUID AQUEOUS PHARMACEUTICAL COMPOSITION SI, PIM1, PIM3 KDR 2227/4885MAPK1 2653/4885ADORA3 3352/4885
US-12582717-B2 Protein based excipient for active pharmaceutical ingredients MAX, PEPD, RPS27A KDR 4125/4885MAPK1 3721/4885ADORA3 4400/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.