Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 9/20 | 0.59 |
| ▸ | MEN1 | O00255 | 5/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | RAB9A | P51151 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | PKM | P14618 | 2/20 | 0.55 |
| ▸ | GMNN | O75496 | 1/20 | 0.55 |
| ▸ | TTR | P02766 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.55 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25342600 | 1.00 | DHODH (0.59) | DHODHMEN1KMT2ARAB9ALMNA | |
| SCHEMBL29412850 | 0.82 | DHODH (0.49) | DHODHMEN1KMT2ARAB9ALMNA | |
| SCHEMBL29412857 | 0.82 | DHODH (0.49) | DHODHMEN1KMT2ARAB9ALMNA | |
| SCHEMBL25342511 | 0.82 | DHODH (0.49) | DHODHMEN1KMT2ARAB9ALMNA | |
| SCHEMBL16494401 | 0.80 | RAB9A (0.61) | DHODHMEN1KMT2ARAB9ALMNA | |
| SCHEMBL2627270 | 0.78 | SYK (0.45) | DHODHMEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL15636368 | 0.77 | DHODH (0.72) | DHODHMEN1KMT2ARAB9ALMNA | |
| SCHEMBL15636491 | 0.74 | DHODH (1.00) | DHODHMEN1KMT2ARAB9ALMNA | |
| SCHEMBL3954007 | 0.74 | MEN1 (0.49) | MEN1KMT2ARAB9ALMNAMAPT | |
| SCHEMBL2047264 | 0.74 | DHODH (0.70) | DHODHMEN1KMT2ARAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022060799-A1 | COMPOUNDS WHICH INHIBIT RNA POLYMERASE AND THEIR USE | THE JOHNS HOPKINS UNIVERSITY (US) | 2022-03-24 | — | — | WO | disclosed |