Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 8/20 | 0.41 |
| ▸ | HTR2C | P28335 | 7/20 | 0.41 |
| ▸ | HTR2A | P28223 | 6/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.40 |
| ▸ | HTR3B | O95264 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.40 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.40 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28692317 | 1.00 | HTR2B (0.41) | HTR2BHTR2CHTR2APARP1HTR3E | |
| SCHEMBL30069969 | 0.87 | PARP1 (0.43) | HTR2BHTR2CHTR2APARP1HTR3E | |
| SCHEMBL30493286 | 0.80 | STAT3 (0.44) | HTR2BHTR2CHTR2APARP1HTR3E | |
| SCHEMBL28650618 | 0.79 | STAT3 (0.39) | HTR2BHTR2CHTR2APARP1HTR3E | |
| SCHEMBL22940891 | 0.77 | CRBN (0.59) | MAP1LC3BJAK2CRBNAXL | |
| SCHEMBL660471 | 0.74 | HTR2B (0.62) | HTR2BHTR2CHTR2APARP1HTR3E | |
| SCHEMBL30659847 | 0.74 | PARP1 (0.49) | HTR2BHTR2CHTR2APARP1HTR3E | |
| SCHEMBL30376302 | 0.74 | HTR2B (0.62) | HTR2BHTR2CHTR2APARP1HTR3E | |
| SCHEMBL30698072 | 0.74 | HTR2B (0.62) | HTR2BHTR2CHTR2APARP1HTR3E | |
| SCHEMBL30459956 | 0.73 | HTR2B (0.50) | HTR2BHTR2CHTR2APARP1HTR3E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114174299-A | Degradation of Bruton's Tyrosine Kinase (BTK) by conjugation of BTK inhibitors to E3 ligase ligands and methods of use | 百济神州有限公司 | 2022-03-11 | — | — | CN | disclosed |