Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.47 |
| ▸ | CCR2 | P41597 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | VNN1 | O95497 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.43 |
| ▸ | FEN1 | P39748 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.42 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | ITK | Q08881 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19207731 | 1.00 | RIPK1 (0.51) | RIPK1CYP19A1CYP11B1CYP11B2CCR2 | |
| SCHEMBL19224666 | 0.85 | RIPK1 (0.52) | RIPK1CYP19A1CYP11B1CYP11B2FAAH | |
| SCHEMBL29415736 | 0.85 | RIPK1 (0.52) | RIPK1CYP19A1CYP11B1CYP11B2FAAH | |
| SCHEMBL13529255 | 0.84 | CYP19A1 (0.49) | CYP19A1CYP11B1CYP11B2HDAC1HDAC6 | |
| SCHEMBL1414358 | 0.80 | KLKB1 (0.49) | RIPK1CYP19A1HDAC1HDAC6 | |
| SCHEMBL18366879 | 0.80 | HDAC1 (0.49) | CYP11B1CYP11B2CCR2HDAC1HDAC6 | |
| SCHEMBL30092734 | 0.80 | HDAC1 (0.49) | CYP11B1CYP11B2CCR2HDAC1HDAC6 | |
| SCHEMBL30587649 | 0.80 | KDM4C (0.49) | RIPK1CYP11B1CYP11B2HDAC1HDAC6 | |
| SCHEMBL18366899 | 0.80 | KDM4C (0.49) | RIPK1CYP11B1CYP11B2HDAC1HDAC6 | |
| SCHEMBL24991855 | 0.78 | CYP19A1 (0.48) | CYP19A1CYP11B1CYP11B2CCR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118994191-A | Inhibitors of receptor interacting protein kinase 1 | 戴纳立制药公司 | 2024-11-22 | — | — | CN | disclosed |
| CN-118994190-A | Inhibitors of receptor interacting protein kinase 1 | 戴纳立制药公司 | 2024-11-22 | — | — | CN | disclosed |
| CN-114437105-B | Inhibitors of receptor interacting protein kinase 1 | 戴纳立制药公司 | 2024-10-11 | — | — | CN | disclosed |
| CN-114437105-A | Inhibitors of receptor interacting protein kinase 1 | 戴纳立制药公司 | 2022-05-06 | — | — | CN | disclosed |
| CN-109071504-B | Inhibitors of receptor interacting protein kinase 1 | 戴纳立制药公司 | 2022-03-08 | — | — | CN | disclosed |