Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.52 |
| ▸ | VNN1 | O95497 | 4/20 | 0.45 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.45 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | GPR6 | P46095 | 1/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.42 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19224666 | 1.00 | RIPK1 (0.52) | RIPK1VNN1MRGPRX4CREBBPRXFP1 | |
| SCHEMBL19207731 | 0.85 | RIPK1 (0.51) | RIPK1VNN1CREBBPCYP11B1CYP11B2 | |
| SCHEMBL29415636 | 0.85 | RIPK1 (0.51) | RIPK1VNN1CREBBPCYP11B1CYP11B2 | |
| SCHEMBL30587599 | 0.82 | L3MBTL1 (0.47) | RIPK1MRGPRX4GRIN1GRIN2B | |
| SCHEMBL18366875 | 0.82 | HDAC1 (0.48) | — | |
| SCHEMBL18366896 | 0.82 | L3MBTL1 (0.47) | RIPK1MRGPRX4GRIN1GRIN2B | |
| SCHEMBL30587560 | 0.82 | HDAC1 (0.48) | — | |
| SCHEMBL1414421 | 0.81 | KLKB1 (0.50) | RIPK1 | |
| SCHEMBL31487689 | 0.77 | SLC7A5 (0.46) | MRGPRX4YTHDC1 | |
| SCHEMBL20594696 | 0.77 | NOTUM (0.58) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118994190-A | Inhibitors of receptor interacting protein kinase 1 | 戴纳立制药公司 | 2024-11-22 | — | — | CN | disclosed |
| CN-118994191-A | Inhibitors of receptor interacting protein kinase 1 | 戴纳立制药公司 | 2024-11-22 | — | — | CN | disclosed |
| CN-114437105-B | Inhibitors of receptor interacting protein kinase 1 | 戴纳立制药公司 | 2024-10-11 | — | — | CN | disclosed |
| CN-114437105-A | Inhibitors of receptor interacting protein kinase 1 | 戴纳立制药公司 | 2022-05-06 | — | — | CN | disclosed |
| CN-109071504-B | Inhibitors of receptor interacting protein kinase 1 | 戴纳立制药公司 | 2022-03-08 | — | — | CN | disclosed |