Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 19/20 | 0.52 |
| ▸ | THRA | P10827 | 14/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.34 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.34 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22632821 | 0.84 | THRB (0.52) | THRBTHRACYP2C9UGT1A1ABCG2 | |
| SCHEMBL28651241 | 0.81 | THRB (0.51) | THRBTHRACYP2C9UGT1A1ABCG2 | |
| SCHEMBL28651291 | 0.79 | THRB (0.52) | THRBTHRACYP2C9UGT1A1ABCG2 | |
| SCHEMBL28442792 | 0.79 | THRB (0.56) | THRBTHRACYP2C9UGT1A1ABCG2 | |
| SCHEMBL28651437 | 0.78 | THRB (0.51) | THRBTHRACYP2C9UGT1A1ABCG2 | |
| SCHEMBL29986198 | 0.76 | THRB (0.46) | THRBTHRA | |
| SCHEMBL28698594 | 0.76 | THRB (0.47) | THRBTHRA | |
| SCHEMBL22632380 | 0.74 | THRB (0.66) | THRBTHRACYP2C9UGT1A1ABCG2 | |
| SCHEMBL22632378 | 0.74 | THRA (0.67) | THRBTHRACYP2C9UGT1A1ABCG2 | |
| SCHEMBL28924887 | 0.73 | THRB (0.62) | THRBTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112645936-B | Substituted pyridazinone compound and use thereof | 山东第一医科大学(山东省医学科学院) | 2022-03-01 | — | — | CN | disclosed |