SCHEMBL29419166

SCHEMBL29419166

COC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)OC(C)(C)C

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TACR1 P25103 2/20 0.65
KMT2A Q03164 4/20 0.64
MEN1 O00255 3/20 0.64
HCRTR1 O43613 1/20 0.64
CTSL P07711 2/20 0.61
CTSS P25774 1/20 0.61
CTSK P43235 1/20 0.61
ACE P12821 1/20 0.58
MAPT P10636 4/20 0.58
NPBWR1 P48145 1/20 0.58
MCHR1 Q99705 1/20 0.58
HDAC3 O15379 3/20 0.57
HDAC4 P56524 3/20 0.57
HDAC1 Q13547 3/20 0.57
HDAC7 Q8WUI4 3/20 0.57
HDAC2 Q92769 3/20 0.57
HDAC10 Q969S8 3/20 0.57
HDAC11 Q96DB2 3/20 0.57
HDAC8 Q9BY41 3/20 0.57
HDAC6 Q9UBN7 3/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27902203 0.91 ACE (0.69) TACR1KMT2AMEN1CTSLCTSS
SCHEMBL27902201 0.91 ACE (0.69) TACR1KMT2AMEN1CTSLCTSS
SCHEMBL31465284 0.91 ACE (0.69) TACR1KMT2AMEN1CTSLCTSS
SCHEMBL27951096 0.90 TACR1 (0.71) TACR1KMT2AMEN1CTSLCTSS
SCHEMBL27951093 0.90 TACR1 (0.71) TACR1KMT2AMEN1CTSLCTSS
SCHEMBL621684 0.90 TACR1 (0.78) TACR1KMT2AMEN1HCRTR1CTSL
SCHEMBL1486155 0.90 TACR1 (0.78) TACR1KMT2AMEN1HCRTR1CTSL
SCHEMBL29400174 0.90 TACR1 (0.78) TACR1KMT2AMEN1HCRTR1CTSL
SCHEMBL5251038 0.90 TACR1 (0.78) TACR1KMT2AMEN1HCRTR1CTSL
SCHEMBL28926367 0.89 KMT2A (0.71) TACR1KMT2AMEN1HCRTR1CTSL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112062704-B Preparation method of trifluoromethylated polypeptide compound 浙江工业大学 2022-03-18 CN disclosed