Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.47 |
| ▸ | PDK2 | Q15119 | 4/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.41 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.41 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.41 |
| ▸ | ALPL | P05186 | 2/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14914823 | 1.00 | NOTUM (0.47) | NOTUMPDK2PDK1PDK3PDK4 | |
| SCHEMBL25371993 | 0.85 | PDK2 (0.46) | NOTUMPDK2PDK1PDK3PDK4 | |
| SCHEMBL10322914 | 0.84 | KDM4E (0.46) | NOTUMPDK2PDK1PDK3PDK4 | |
| SCHEMBL25564366 | 0.84 | NOTUM (0.48) | NOTUMPDK2ALPLMRGPRX4CA12 | |
| SCHEMBL14915765 | 0.83 | MRGPRX4 (0.44) | ALPLMRGPRX4POLB | |
| SCHEMBL20763421 | 0.83 | KMT2A (0.48) | NOTUMCA12CA1CA2CA7 | |
| SCHEMBL10322996 | 0.82 | ALDH1A1 (0.52) | NOTUMPDK2PDK1PDK3PDK4 | |
| SCHEMBL14914880 | 0.82 | ALPL (0.43) | NOTUMPDK2PDK1PDK3PDK4 | |
| SCHEMBL29422733 | 0.82 | ALPL (0.43) | NOTUMPDK2PDK1PDK3PDK4 | |
| SCHEMBL8336289 | 0.81 | CA1 (0.52) | NOTUMPDK2PDK1PDK3PDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3953351-A1 | CONDENSED AZINES FOR EP300 OR CBP MODULATION AND INDICATIONS THEREFOR | Plexxikon Inc. (US) | 2022-02-16 | — | — | EP | disclosed |