Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.54 |
| ▸ | RAB9A | P51151 | 8/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.46 |
| ▸ | RELA | Q04206 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 6/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | F10 | P00742 | 7/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13665243 | 0.92 | SMN1; SMN2 (0.52) | SMN1; SMN2RAB9ANFKB1NFKB2RELA | |
| SCHEMBL2941972 | 0.88 | SMN1; SMN2 (0.55) | SMN1; SMN2RAB9ANFKB1NFKB2RELA | |
| SCHEMBL2945609 | 0.87 | SMN1; SMN2 (0.57) | SMN1; SMN2RAB9ANFKB1NFKB2RELA | |
| SCHEMBL13515796 | 0.86 | SMN1; SMN2 (0.61) | SMN1; SMN2RAB9ANFKB1NFKB2RELA | |
| SCHEMBL13665190 | 0.84 | SMN1; SMN2 (0.62) | SMN1; SMN2RAB9ANFKB1NFKB2RELA | |
| SCHEMBL13291234 | 0.84 | SMN1; SMN2 (0.49) | SMN1; SMN2RAB9ANFKB1NFKB2RELA | |
| SCHEMBL13515771 | 0.83 | SMN1; SMN2 (0.54) | SMN1; SMN2RAB9ANFKB1NFKB2RELA | |
| SCHEMBL2951090 | 0.83 | SMN1; SMN2 (0.57) | SMN1; SMN2RAB9ANFKB1NFKB2RELA | |
| SCHEMBL13665191 | 0.82 | SORT1 (0.57) | SMN1; SMN2RAB9ANFKB1NFKB2RELA | |
| SCHEMBL13665206 | 0.82 | RAB9A (0.63) | SMN1; SMN2RAB9ANFKB1NFKB2RELA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1489078-B1 | BENZOFURAN DERIVATIVE | MITSUBISHI TANABE PHARMA CORP (JP) | 2010-01-06 | — | — | EP | disclosed |
| US-7605158-B2 | Carbamoyl-type benzofuran derivatives | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2009-10-20 | — | — | US | disclosed |
| US-7605158-B2 | Carbamoyl-type benzofuran derivatives | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2009-10-20 | — | — | US | disclosed |
| US-7605158-B2 | Carbamoyl-type benzofuran derivatives | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2009-10-20 | — | — | US | disclosed |
| US-20090209511-A1 | Benzofuran Derivatives | KAWAGUCHI TAKAYUKI | 2009-08-20 | — | — | US | disclosed |
| US-20090209511-A1 | Benzofuran Derivatives | KAWAGUCHI TAKAYUKI | 2009-08-20 | — | — | US | disclosed |
| US-20090209511-A1 | Benzofuran Derivatives | KAWAGUCHI TAKAYUKI | 2009-08-20 | — | — | US | disclosed |
| US-7531537-B2 | Benzofuran derivative | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2009-05-12 | — | — | US | disclosed |
| CN-100439351-C | Benzofuran derivative | TANABE SEIYAKU CO (JP) | 2008-12-03 | — | — | CN | disclosed |
| CN-100430392-C | Carbamoyl-type benzofuran derivatives | TANABE SEIYAKU CO (JP) | 2008-11-05 | — | — | CN | disclosed |
| US-20060247273-A1 | Carbamoyl-type benzofuran derivatives | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2006-11-02 | — | — | US | disclosed |
| CN-1856488-A | Carbamoyl-type benzofuran derivatives | TANABE SEIYAKU CO (JP) | 2006-11-01 | — | — | CN | disclosed |
| EP-1666478-A1 | CARBAMOYL-TYPE BENZOFURAN DERIVATIVES | TANABE SEIYAKU CO., LTD. (JP) | 2006-06-07 | — | — | EP | disclosed |
| US-20050282808-A1 | Benzofuran derivative | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2005-12-22 | — | — | US | disclosed |
| CN-1656086-A | Benzofuran derivative | TANABE SEIYAKU CO (JP) | 2005-08-17 | — | — | CN | disclosed |
| EP-1489078-A1 | BENZOFURAN DERIVATIVE | Tanabe Seiyaku Co., Ltd. (JP) | 2004-12-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050282808-A1 | Benzofuran derivative | F12, F2, F11 | SMN1; SMN2 3151/4885RAB9A 4616/4885NFKB1 1176/4885 |
| US-20060247273-A1 | Carbamoyl-type benzofuran derivatives | F12, F2, F3 | SMN1; SMN2 4587/4885RAB9A 2276/4885NFKB1 2200/4885 |
| US-20090209511-A1 | Benzofuran Derivatives | F12, F2, F3 | SMN1; SMN2 3067/4885RAB9A 4600/4885NFKB1 1171/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.