Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF4A3 | P38919 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | APEX1 | P27695 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.45 |
| ▸ | RHEB | Q15382 | 4/20 | 0.44 |
| ▸ | IDO1 | P14902 | 3/20 | 0.43 |
| ▸ | TDO2 | P48775 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22394978 | 1.00 | EIF4A3 (0.51) | EIF4A3KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL29301286 | 0.87 | KDM4E (0.49) | EIF4A3KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL30147446 | 0.87 | KDM4E (0.49) | EIF4A3KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL30147558 | 0.83 | KMT2A (0.43) | EIF4A3KDM4EGRIN1 | |
| SCHEMBL22620764 | 0.83 | ULK1 (0.46) | EIF4A3KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL1144892 | 0.81 | EIF4A3 (0.63) | EIF4A3KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL29655546 | 0.81 | EIF4A3 (0.63) | EIF4A3KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL20505503 | 0.80 | EIF4A3 (0.54) | EIF4A3KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL29974750 | 0.80 | EIF4A3 (0.54) | EIF4A3KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL1957687 | 0.79 | KDM4E (0.53) | EIF4A3KDM4EALDH1A1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4149945-A1 | SUBSTITUTED TRICYCLIC AMIDES, ANALOGUES THEREOF, AND METHODS USING SAME | Arbutus Biopharma Corporation (CA) | 2023-03-22 | — | — | EP | disclosed |
| EP-3962914-A1 | NOVEL INDOLE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV) | AiCuris GmbH & Co. KG (DE) | 2022-03-09 | — | — | EP | disclosed |