Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 15/20 | 0.56 |
| ▸ | BRAF | P15056 | 14/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17591679 | 1.00 | RAF1 (0.56) | RAF1BRAFNPC1LMNARAB9A | |
| SCHEMBL30405369 | 0.84 | NPC1 (0.56) | RAF1BRAFNPC1LMNARAB9A | |
| SCHEMBL23482203 | 0.84 | NPC1 (0.56) | RAF1BRAFNPC1LMNARAB9A | |
| SCHEMBL16036520 | 0.84 | RAF1 (0.59) | RAF1BRAF | |
| SCHEMBL26165531 | 0.84 | SLC6A3 (0.47) | NPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL16036513 | 0.83 | KCNQ3 (0.65) | RAF1BRAFLMNARAB9A | |
| SCHEMBL30016396 | 0.81 | LMNA (0.51) | RAF1BRAFNPC1LMNARAB9A | |
| SCHEMBL28637538 | 0.81 | LMNA (0.51) | RAF1BRAFNPC1LMNARAB9A | |
| SCHEMBL17542187 | 0.80 | LMNA (0.59) | NPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL25984181 | 0.79 | RAF1 (0.63) | RAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116761801-A | Heterocyclic compounds having protein kinase inhibitory activity, pharmaceutical compositions containing the same, and methods of preparing and using the same | 四川科伦博泰生物医药股份有限公司 | 2023-09-15 | — | — | CN | disclosed |
| EP-3962484-A1 | INHIBITORS OF RAF KINASES | Kinnate Biopharma Inc. (US) | 2022-03-09 | — | — | EP | disclosed |