Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | RAF1 | P04049 | 1/20 | 0.49 |
| ▸ | BRAF | P15056 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28637538 | 1.00 | LMNA (0.51) | LMNANPC1RAB9ASMN1; SMN2RAF1 | |
| SCHEMBL25984106 | 0.91 | LMNA (0.56) | LMNANPC1RAB9ASMN1; SMN2RAF1 | |
| SCHEMBL30405369 | 0.86 | NPC1 (0.56) | LMNANPC1RAB9ASMN1; SMN2RAF1 | |
| SCHEMBL23482203 | 0.86 | NPC1 (0.56) | LMNANPC1RAB9ASMN1; SMN2RAF1 | |
| SCHEMBL17542187 | 0.84 | LMNA (0.59) | LMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL25984085 | 0.81 | LMNA (0.55) | LMNANPC1RAB9ASMN1; SMN2RAF1 | |
| SCHEMBL29427240 | 0.81 | RAF1 (0.56) | LMNANPC1RAB9ASMN1; SMN2RAF1 | |
| SCHEMBL17591679 | 0.81 | RAF1 (0.56) | LMNANPC1RAB9ASMN1; SMN2RAF1 | |
| SCHEMBL26165525 | 0.80 | RAB9A (0.60) | LMNANPC1RAB9ASMN1; SMN2RAF1 | |
| SCHEMBL23309569 | 0.79 | LMNA (0.74) | LMNANPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113264945-B | Spiro derivative, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2022-11-22 | — | — | CN | disclosed |