Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 5/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | RET | P07949 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 3/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3712259 | 0.95 | MEN1 (0.46) | MEN1KMT2AEGFRNPC1RAB9A | |
| SCHEMBL1012600 | 0.80 | MEN1 (0.32) | MEN1KMT2A | |
| SCHEMBL31319696 | 0.80 | MEN1 (0.32) | MEN1KMT2A | |
| SCHEMBL1256324 | 0.80 | MEN1 (0.32) | MEN1KMT2A | |
| SCHEMBL23982534 | 0.77 | MEN1 (0.31) | MEN1KMT2AEGFR | |
| SCHEMBL11291871 | 0.77 | MEN1 (0.31) | MEN1KMT2AEGFR | |
| SCHEMBL769538 | 0.77 | EGFR (0.33) | MEN1KMT2AEGFRKDR | |
| SCHEMBL17732311 | 0.77 | HSD17B10 (0.39) | MEN1KMT2A | |
| SCHEMBL2677760 | 0.77 | MEN1 (0.31) | MEN1KMT2AEGFRNPC1RAB9A | |
| SCHEMBL1013121 | 0.77 | MEN1 (0.31) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100173917-A1 | UREA DERIVATIVES AS ABL MODULATORS | AMBIT BIOSCIENCES CORPORATION | 2010-07-08 | — | — | US | disclosed |
| US-7750160-B2 | Isoxazolyl urea derivatives as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-07-06 | — | — | US | disclosed |
| EP-1684762-A4 | UREA DERIVATIVES AS KINASE MODULATORS | AMBIT BIOSCIENCES CORP (US) | 2009-06-17 | — | — | EP | disclosed |
| EP-1684762-A2 | UREA DERIVATIVES AS KINASE MODULATORS | Ambit Biosciences Corporation (US) | 2006-08-02 | — | — | EP | disclosed |
| US-20050267182-A1 | Urea derivatives as FLT-3 modulators | AMBIT BIOSCIENCES CORPORATION | 2005-12-01 | — | — | US | disclosed |
| US-20050197371-A1 | Urea derivatives as PDGFR modulators | AMBIT BIOSCIENCES CORPORATION | 2005-09-08 | — | — | US | disclosed |
| US-20050192314-A1 | Urea derivatives as C-kit modulators | AMBIT BIOSCIENCES CORPORATION | 2005-09-01 | — | — | US | disclosed |
| US-20050165031-A1 | Urea derivatives as ABL modulators | AMBIT BIOSCIENCES CORPORATION | 2005-07-28 | — | — | US | disclosed |
| US-20050165024-A1 | Urea derivatives as kinase modulators | AMBIT BIOSCIENCES CORPORATION | 2005-07-28 | — | — | US | disclosed |
| WO-2005048948-A2 | UREA DERIVATIVES AS KINASE MODULATORS | AMBIT BIOSCIENCES CORPORATION (US) | 2005-06-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050165024-A1 | Urea derivatives as kinase modulators | ULK2, ULK1, ULK3 | MEN1 4259/4885KMT2A 1390/4885EGFR 971/4885 |
| US-20100173917-A1 | UREA DERIVATIVES AS ABL MODULATORS | ABL1, ABL2, BCR | MEN1 4362/4885KMT2A 285/4885EGFR 196/4885 |
| US-20050192314-A1 | Urea derivatives as C-kit modulators | KIT, PRKCH, PRKCE | MEN1 2079/4885KMT2A 639/4885EGFR 942/4885 |
| US-20050267182-A1 | Urea derivatives as FLT-3 modulators | FLT4, FLT1, FLT3 | MEN1 3423/4885KMT2A 1637/4885EGFR 215/4885 |
| US-20050197371-A1 | Urea derivatives as PDGFR modulators | PDGFRA, PDGFRB, PDGFA | MEN1 4597/4885KMT2A 2832/4885EGFR 17/4885 |
| US-20050165031-A1 | Urea derivatives as ABL modulators | ABL1, ABL2, BCR | MEN1 4362/4885KMT2A 285/4885EGFR 196/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.