Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | CA5A | P35218 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29433670 | 1.00 | MAPT (0.46) | MAPTLMNAALDH1A1PDK2SMN1; SMN2 | |
| SCHEMBL28718593 | 0.88 | MAPT (0.43) | MAPTLMNAALDH1A1PDK2SMN1; SMN2 | |
| SCHEMBL29433673 | 0.88 | MAPT (0.43) | MAPTLMNAALDH1A1PDK2SMN1; SMN2 | |
| SCHEMBL2394813 | 0.80 | MAPT (0.53) | MAPTLMNAALDH1A1PDK2SMN1; SMN2 | |
| SCHEMBL14304472 | 0.79 | ALDH1A1 (0.55) | MAPTLMNAALDH1A1SMN1; SMN2GPR119 | |
| SCHEMBL3201431 | 0.77 | CA12 (0.52) | MAPTLMNAALDH1A1PDK2SMN1; SMN2 | |
| SCHEMBL21113046 | 0.77 | MAPT (0.49) | MAPTLMNAALDH1A1PDK2SMN1; SMN2 | |
| SCHEMBL29433684 | 0.76 | KDM4E (0.35) | MAPTLMNAALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL28707411 | 0.76 | KDM4E (0.35) | MAPTLMNAALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL20231910 | 0.75 | MAPT (0.52) | MAPTLMNAALDH1A1PDK2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114163444-B | Chimeric compound for androgen receptor protein targeted degradation, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2023-07-14 | — | — | CN | disclosed |
| CN-114163444-A | Chimeric compound for targeted degradation of androgen receptor protein, preparation method thereof and application thereof in medicine | 江苏恒瑞医药股份有限公司 | 2022-03-11 | — | — | CN | disclosed |