Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.32 |
| ▸ | CHRNA1 | P02708 | 3/20 | 0.32 |
| ▸ | CHRNG | P07510 | 3/20 | 0.32 |
| ▸ | CHRNB1 | P11230 | 3/20 | 0.32 |
| ▸ | CHRND | Q07001 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | THPO | P40225 | 1/20 | 0.32 |
| ▸ | CHRNE | Q04844 | 1/20 | 0.32 |
| ▸ | CHRNA2 | Q15822 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28193800 | 0.84 | NPSR1 (0.33) | NPSR1CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL29525553 | 0.84 | MAPK1 (0.33) | NPSR1CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL27874091 | 0.81 | TDP1 (0.34) | NPSR1 | |
| SCHEMBL31408631 | 0.79 | NPSR1 (0.31) | NPSR1 | |
| SCHEMBL27584019 | 0.73 | NPSR1 (0.31) | NPSR1 | |
| SCHEMBL7657874 | 0.71 | HSD11B1 (0.43) | CHRNB2CHRNA3CHRNA4 | |
| SCHEMBL7657865 | 0.71 | HSD11B1 (0.43) | CHRNB2CHRNA3CHRNA4 | |
| SCHEMBL5127284 | 0.65 | — | — | |
| SCHEMBL5940727 | 0.65 | CHRNB2 (0.32) | NPSR1CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL5478238 | 0.64 | CHRNB2 (0.33) | CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4276095-A2 | PROCESSES FOR PREPARING ASK1 INHIBITORS | Gilead Sciences, Inc. (US) | 2023-11-15 | — | — | EP | disclosed |
| EP-3693366-B1 | PROCESSES FOR PREPARING ASK1 INHIBITORS | GILEAD SCIENCES INC (US) | 2023-06-28 | — | — | EP | disclosed |
| EP-4126242-A1 | TRICYCLIC INHIBITORS OF INFLUENZA VIRUS ENDONUCLEASE | SRI International (US) | 2023-02-08 | — | — | EP | disclosed |
| US-20220135527-A1 | PROCESSES FOR PREPARING ASK1 INHIBITORS | GILEAD SCIENCES, INC. | 2022-05-05 | — | — | US | disclosed |
| US-11261161-B2 | Processes for preparing ASK1 inhibitors | GILEAD SCIENCES, INC. (US) | 2022-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11261161-B2 | Processes for preparing ASK1 inhibitors | MAP3K1, MAP3K6, MAP3K7 | NPSR1 4570/4885CHRNB2 4820/4885CHRNB4 4843/4885 |
| US-20220135527-A1 | PROCESSES FOR PREPARING ASK1 INHIBITORS | MAP3K1, MAP3K6, MAP3K7 | NPSR1 4570/4885CHRNB2 4820/4885CHRNB4 4843/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.