Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nordihydroguaiaretic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R known ✓ | P08069 | 2/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 9/20 | 1.00 |
| ▸ | ALOX12 | P18054 | 7/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 1.00 |
| ▸ | RECQL | P46063 | 3/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 3/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | ESR1 | P03372 | 2/20 | 1.00 |
| ▸ | TP53 | P04637 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | HPGD | P15428 | 2/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | NR3C1 | P04150 | 2/20 | 1.00 |
| ▸ | FOS | P01100 | 2/20 | 1.00 |
| ▸ | TTR | P02766 | 2/20 | 1.00 |
| ▸ | JUN | P05412 | 2/20 | 1.00 |
| ▸ | HSD17B1 | P14061 | 2/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nordihydroguaiaretic Acid SCHEMBL13906133 | 1.00 | ALOX15 (1.00) | ALOX15ALOX12KDM4ERECQLHIF1A | |
| Masoprocol SCHEMBL3818 | 1.00 | ALOX15 (1.00) | ALOX15ALOX12KDM4ERECQLHIF1A | |
| Nordihydroguaiaretic Acid SCHEMBL29434238 | 1.00 | ALOX15 (1.00) | ALOX15ALOX12KDM4ERECQLHIF1A | |
| Masoprocol SCHEMBL29355090 | 1.00 | ALOX15 (1.00) | ALOX15ALOX12KDM4ERECQLHIF1A | |
| Nordihydroguaiaretic Acid SCHEMBL135976 | 1.00 | ALOX15 (1.00) | ALOX15ALOX12KDM4ERECQLHIF1A | |
| Masoprocol SCHEMBL29350884 | 1.00 | ALOX15 (1.00) | ALOX15ALOX12KDM4ERECQLHIF1A | |
| Masoprocol SCHEMBL28156467 | 0.98 | ALOX15 (0.96) | ALOX15ALOX12KDM4ERECQLHIF1A | |
| SCHEMBL2227757 | 0.96 | ALOX15 (0.92) | ALOX15ALOX12KDM4ERECQLHIF1A | |
| Masoprocol SCHEMBL2304515 | 0.94 | ALOX15 (0.88) | ALOX15ALOX12KDM4ERECQLHIF1A | |
| Nordihydroguaiaretic Acid SCHEMBL28026820 | 0.94 | ALOX15 (0.88) | ALOX15ALOX12KDM4ERECQLHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 71 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4727986-A1 | ABRASIVE ARTICLE | August Rüggeberg GmbH & Co. KG (DE) | 2026-04-22 | — | — | EP | claimed |
| WO-2025131235-A1 | ABRASIVE ARTICLE | AUGUST RÜGGEBERG GMBH & CO. KG (DE) | 2025-06-26 | — | — | WO | claimed |
| US-20250201455-A1 | High temperature resistant magnet and a preparation method thereof | YANTAI DONGXING MAGNETIC MAT INC (CN) | 2025-06-19 | — | — | US | claimed |
| EP-4156213-B1 | MANUFACTURING METHOD OF A HIGH TEMPERATURE RESISTANT MAGNET | YANTAI DONGXING MAGNETIC MAT INC (CN) | 2025-05-21 | — | — | EP | claimed |
| EP-4156214-B1 | MANUFACTURING METHOD OF A LOW-HEAVY RARE EARTH MAGNET | YANTAI DONGXING MAGNETIC MAT INC (CN) | 2025-05-21 | — | — | EP | claimed |
| CN-113871121-B | High-temperature-resistant magnet and manufacturing method thereof | 烟台东星磁性材料股份有限公司 | 2024-12-03 | — | — | CN | claimed |
| CN-113871122-B | Low-weight rare earth magnet and manufacturing method thereof | 烟台东星磁性材料股份有限公司 | 2024-11-15 | — | — | CN | claimed |
| US-20240238254-A1 | PHARMACOLOGICAL INTERVENTION OF THE ARACHIDONIC ACID PATHWAY TO CURE AMYOTROPHIC LATERAL SCLEROSIS | THE JOHNS HOPKINS UNIVERSITY (US) | 2024-07-18 | — | — | US | claimed |
| EP-4192538-A1 | MEDICAL DEVICES HAVING AN IMMEDIATELY DETACHABLE, PERMANENTLY PROLIFERATION-INHIBITING COATING COMPRISING AT LEAST ONE LIMUS SUBSTANCE AND METHOD OF PRODUCTION | InnoRa Gesellschaft mbH (DE) | 2023-06-14 | — | — | EP | claimed |
| WO-2023064318-A1 | BIPHASIC COMPOSITIONS COMPRISING ONE OR BOTH OF CARBONATE AND PHOSPHATE | Natural Extraction Systems, LLC (US) | 2023-04-20 | — | — | WO | claimed |
| US-20230095310-A1 | Low-heavy rare earth magnet and manufacturing method thereof | YANTAI DONGXING MAGNETIC MAT INC (CN) | 2023-03-30 | — | — | US | claimed |
| EP-4156213-A1 | A HIGH TEMPERATURE RESISTANT MAGNET AND A METHOD THEREOF | Yantai Dongxing Magnetic Materials Inc. (CN) | 2023-03-29 | — | — | EP | claimed |
| EP-4156214-A1 | A LOW-HEAVY RARE EARTH MAGNET AND MANUFACTURING METHOD | Yantai Dongxing Magnetic Materials Inc. (CN) | 2023-03-29 | — | — | EP | claimed |
| CN-115809427-A | Mixed gas identification method based on mixed strategy optimization BP neural network | 山东科技大学 | 2023-03-17 | — | — | CN | claimed |
| WO-2022251254-A1 | PHARMACOLOGICAL INTERVENTION OF THE ARACHIDONIC ACID PATHWAY TO CURE AMYOTROPHIC LATERAL SCLEROSIS | THE JOHNS HOPKINS UNIVERSITY (US) | 2022-12-01 | — | — | WO | claimed |
| CN-115182047-A | Self-activated gallium tetraborate crystal, bonded crystal, and preparation method and application of crystal | 中国科学院福建物质结构研究所 | 2022-10-14 | — | — | CN | claimed |
| WO-2022182527-A1 | COMPOSITIONS AND METHODS RELATED TO PHARMACEUTICAL EXCIPIENTS | Natural Extraction Systems, LLC (US) | 2022-09-01 | — | — | WO | claimed |
| WO-2026087745-A1 | AN ANTIOXIDANT COMPOSITION COMPRISING A CINNAMIC ACID DERIVATIVE | BRAIN Biotech AG (DE) | 2026-04-30 | — | — | WO | disclosed |
| US-11278026-B2 | Composition based on nordihydroguaiaretic acid | PROMOTORA TECNICA INDUSTRIAL, S.A. DE C.V. (MX) | 2022-03-22 | — | — | US | disclosed |
| US-11278026-B2 | Composition based on nordihydroguaiaretic acid | PROMOTORA TECNICA INDUSTRIAL, S.A. DE C.V. (MX) | 2022-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11278026-B2 | Composition based on nordihydroguaiaretic acid | DDT, DHRS9, DAGLA | IGF1R 1509/4885ALOX15 557/4885ALOX12 347/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.