Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PTGES2 | Q9H7Z7 | 4/20 | 0.46 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.45 |
| ▸ | EDNRA | P25101 | 2/20 | 0.45 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ACLY | P53396 | 2/20 | 0.43 |
| ▸ | EDNRB | P24530 | 1/20 | 0.43 |
| ▸ | SGK1 | O00141 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22981720 | 1.00 | MCL1 (0.48) | MCL1LMNAGAAPTGES2SLC22A12 | |
| SCHEMBL22980387 | 0.85 | LMNA (0.51) | MCL1LMNAGAAPTGES2SLC22A12 | |
| SCHEMBL29434885 | 0.85 | LMNA (0.51) | MCL1LMNAGAAPTGES2SLC22A12 | |
| SCHEMBL29434842 | 0.80 | SLC22A12 (0.44) | MCL1LMNAGAAPTGES2SLC22A12 | |
| SCHEMBL22980417 | 0.80 | MCL1 (0.45) | MCL1LMNAGAASLC22A12EDNRA | |
| SCHEMBL22981705 | 0.80 | SLC22A12 (0.44) | MCL1LMNAGAAPTGES2SLC22A12 | |
| SCHEMBL29335253 | 0.77 | PTGES2 (0.53) | MCL1PTGES2ACLY | |
| SCHEMBL14433750 | 0.75 | PGR (0.54) | MCL1PTGES2SLC22A12PGRPKM | |
| SCHEMBL29118833 | 0.74 | PGR (0.65) | LMNASLC22A12PGRMEN1KMT2A | |
| SCHEMBL30737482 | 0.74 | MEN1 (0.65) | SLC22A12PGRMEN1KMT2ASGK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4013495-A1 | ARYLSULFONAMIDE DERIVATIVES AS MGLUR4 NEGATIVE ALLOSTERIC MODULATORS | F. Hoffmann-La Roche AG (CH) | 2022-06-22 | — | — | EP | disclosed |
| CN-114174266-A | Arylsulfonamide derivatives as MGLUR4 negative allosteric modulators | 豪夫迈·罗氏有限公司 | 2022-03-11 | — | — | CN | disclosed |