Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 2/20 | 0.52 |
| ▸ | APLNR | P35414 | 1/20 | 0.47 |
| ▸ | NOS3 | P29474 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | MIF | P14174 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | CTH | P32929 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CCR1 | P32246 | 1/20 | 0.32 |
| ▸ | CCR8 | P51685 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2924950 | 1.00 | PLAU (0.52) | PLAUAPLNRNOS3NOS1NOS2 | |
| SCHEMBL23214427 | 0.80 | PLAU (0.52) | PLAUAPLNRNOS3NOS1NOS2 | |
| SCHEMBL7388303 | 0.78 | APLNR (0.58) | PLAUAPLNRMIFGABRA1GABRB2 | |
| SCHEMBL1851255 | 0.76 | PLAU (0.61) | PLAUNOS3NOS1NOS2NPC1 | |
| SCHEMBL3223751 | 0.76 | APLNR (0.43) | PLAUAPLNRKDM4EMAPTMIF | |
| SCHEMBL2931701 | 0.76 | APLNR (0.43) | PLAUAPLNRKDM4EMAPTL3MBTL1 | |
| SCHEMBL384468 | 0.76 | APLNR (0.43) | PLAUAPLNRNPC1RAB9AKDM4E | |
| SCHEMBL22583423 | 0.76 | APLNR (0.44) | PLAUAPLNRMIFGABRA1GABRB2 | |
| SCHEMBL22583182 | 0.76 | APLNR (0.44) | PLAUAPLNRKDM4EMAPTMIF | |
| SCHEMBL22583152 | 0.76 | PLAU (0.56) | PLAUAPLNRNPC1RAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3959207-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES | Celgene Corporation (US) | 2022-03-02 | — | — | EP | disclosed |