Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.66 |
| ▸ | KCNMB4 | Q86W47 | 1/20 | 0.66 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.61 |
| ▸ | NPR1 | P16066 | 1/20 | 0.60 |
| ▸ | NPR3 | P17342 | 1/20 | 0.60 |
| ▸ | TSLP | Q969D9 | 2/20 | 0.60 |
| ▸ | MC4R | P32245 | 2/20 | 0.57 |
| ▸ | MC1R | Q01726 | 2/20 | 0.57 |
| ▸ | MC3R | P41968 | 1/20 | 0.57 |
| ▸ | RXFP4 | Q8TDU9 | 4/20 | 0.57 |
| ▸ | RXFP3 | Q9NSD7 | 4/20 | 0.57 |
| ▸ | F12 | P00748 | 3/20 | 0.57 |
| ▸ | PLAU | P00749 | 1/20 | 0.57 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.57 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.56 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.56 |
| ▸ | F11 | P03951 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29424808 | 0.83 | RXFP1 (0.67) | KCNMA1KCNMB4RXFP1NPR1NPR3 | |
| SCHEMBL29462295 | 0.81 | MC4R (0.70) | KCNMA1KCNMB4RXFP1MC4RMC1R | |
| SCHEMBL29389059 | 0.81 | KCNMA1 (0.66) | KCNMA1KCNMB4RXFP1NPR1NPR3 | |
| Polyphemusin Ii SCHEMBL29449206 | 0.80 | F12 (0.62) | MC4RMC1RF12KLKB1 | |
| SCHEMBL28586826 | 0.80 | RXFP4 (0.61) | RXFP1NPR1NPR3MC4RMC1R | |
| SCHEMBL15186042 | 0.77 | BCL2L1 (0.61) | NPR1NPR3MC4RMC1RMC3R | |
| SCHEMBL29509630 | 0.77 | F12 (0.58) | KCNMA1KCNMB4MC4RMC1RF12 | |
| Carperitide SCHEMBL218549 | 0.77 | NPR1 (0.94) | KCNMA1KCNMB4RXFP1NPR1NPR3 | |
| SCHEMBL31692748 | 0.77 | F12 (0.58) | TSLPF12KLKB1F11 | |
| SCHEMBL15987248 | 0.77 | F12 (0.58) | TSLPF12KLKB1F11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025106656-A1 | METHODS OF PREVENTING OR REDUCING CARTILAGE LOSS AND/OR JOINT DAMAGE USING NAV 1.7 INHIBITORS | YALE UNIVERSITY (US) | 2025-05-22 | — | — | WO | claimed |
| US-20220033795-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF PAIN | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2022-02-03 | — | — | US | claimed |
| WO-2025106656-A1 | METHODS OF PREVENTING OR REDUCING CARTILAGE LOSS AND/OR JOINT DAMAGE USING NAV 1.7 INHIBITORS | YALE UNIVERSITY (US) | 2025-05-22 | — | — | WO | disclosed |
| EP-4537845-A1 | METHOD FOR CONTROLLING MEMBRANE POTENTIAL-DEPENDENT ION CHANNEL THROUGH TYPE I TASTE RECEPTORS (T1RS) | Ion Chat Research Corporate (JP) | 2025-04-16 | — | — | EP | disclosed |
| WO-2023238955-A1 | METHOD FOR CONTROLLING MEMBRANE POTENTIAL-DEPENDENT ION CHANNEL THROUGH TYPE I TASTE RECEPTORS (T1RS) | 株式会社 Ion Chat Research | 2023-12-14 | — | — | WO | disclosed |
| US-20230374084-A1 | POTENT AND SELECTIVE INHIBITORS OF NAV1.7 | ALDEVRON, LLC (US) | 2023-11-23 | — | — | US | disclosed |
| US-11753633-B2 | Compositions and methods for treatment of pain | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-09-12 | — | — | US | disclosed |
| WO-2022066767-A2 | POTENT AND SELECTIVE INHIBITORS OF NAV1.7 | ALDEVRON, LLC (US) | 2022-03-31 | — | — | WO | disclosed |
| EP-3973981-A1 | HUWENTOXIN-IV VARIANTS AND METHODS OF USE | Janssen Biotech, Inc. (US) | 2022-03-30 | — | — | EP | disclosed |
| US-20220089663-A1 | PROTEINS AND FLUOROPHORE-CONTAINING COMPOUNDS SELECTIVE FOR NaV1.7 | MEMORIAL SLOAN KETTERING CANCER CENTER (US) | 2022-03-24 | — | — | US | disclosed |
| US-20220033795-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF PAIN | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2022-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220089663-A1 | PROTEINS AND FLUOROPHORE-CONTAINING COMPOUNDS SELECTIVE FOR NaV1.7 | SCN7A, CACNG7, TRPV1 | KCNMA1 67/4885KCNMB4 63/4885RXFP1 1869/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.