Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 5/20 | 0.61 |
| ▸ | CSNK1A1 | P48729 | 4/20 | 0.61 |
| ▸ | GSK3B | P49841 | 4/20 | 0.61 |
| ▸ | CSNK1G2 | P78368 | 4/20 | 0.61 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.58 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.56 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | METAP2 | P50579 | 1/20 | 0.52 |
| ▸ | METAP1 | P53582 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.49 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.49 |
| ▸ | CFB | P00751 | 4/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12430878 | 1.00 | CSNK1D (0.61) | CSNK1DCSNK1A1GSK3BCSNK1G2PIN1 | |
| SCHEMBL1794997 | 0.86 | CSNK1D (0.47) | CSNK1DCSNK1A1GSK3BCSNK1G2PIN1 | |
| SCHEMBL24463260 | 0.82 | ALDH1A1 (0.56) | CSNK1DCSNK1A1GSK3BCSNK1G2ALDH1A1 | |
| SCHEMBL29727934 | 0.79 | ALDH1A1 (0.66) | PIN1ALDH1A1MAPTKDM4EPKM | |
| SCHEMBL266609 | 0.79 | ALDH1A1 (0.66) | PIN1ALDH1A1MAPTKDM4EPKM | |
| SCHEMBL2712166 | 0.79 | PIN1 (0.62) | CSNK1DCSNK1A1GSK3BCSNK1G2PIN1 | |
| SCHEMBL1245514 | 0.79 | PIN1 (0.58) | CSNK1DCSNK1A1GSK3BCSNK1G2PIN1 | |
| SCHEMBL22219469 | 0.79 | PIN1 (0.58) | CSNK1DCSNK1A1GSK3BCSNK1G2PIN1 | |
| SCHEMBL1793328 | 0.79 | PIN1 (0.58) | CSNK1DCSNK1A1GSK3BCSNK1G2PIN1 | |
| SCHEMBL7792028 | 0.79 | PIN1 (0.58) | CSNK1DCSNK1A1GSK3BCSNK1G2PIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220064150-A1 | SUBSTITUTED REVERSE PYRIMIDINE BMI-1 INHIBITORS | PTC THERAPEUTICS INC (US) | 2022-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220064150-A1 | SUBSTITUTED REVERSE PYRIMIDINE BMI-1 INHIBITORS | BMI1, BRPF3, BAZ2A | CSNK1D 4144/4885CSNK1A1 3432/4885GSK3B 3739/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.