Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 1/20 | 0.49 |
| ▸ | MPI | P34949 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | TTK | P33981 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.34 |
| ▸ | MAP3K14 | Q99558 | 6/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10831975 | 0.81 | MAPT (0.47) | TTKMAPTADORA3ADORA2AADORA1 | |
| SCHEMBL16517440 | 0.79 | SCN9A (0.57) | MAP3K14 | |
| SCHEMBL16516700 | 0.77 | STAT1 (0.49) | MPOMAP3K14ALDH1A1 | |
| SCHEMBL28079257 | 0.75 | MPO (0.43) | MPOMPIFAAHMGLLADORA3 | |
| SCHEMBL25222249 | 0.73 | KHK (0.40) | TTKMAPT | |
| SCHEMBL18131331 | 0.73 | PIK3CD (0.51) | TTK | |
| SCHEMBL16532431 | 0.73 | ELANE (0.51) | MPOMAPTMAP3K14ALDH1A1 | |
| SCHEMBL25678127 | 0.72 | ADORA3 (0.48) | MAPTADORA3ADORA2AADORA1ALDH1A1 | |
| SCHEMBL1308538 | 0.71 | L3MBTL1 (0.59) | MPOMPIFAAHMGLLMAPT | |
| SCHEMBL16532681 | 0.70 | ELANE (0.56) | ADORA1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118908957-A | Small molecule inhibitors of NF- κB induced kinase | 詹森药业有限公司 | 2024-11-08 | — | — | CN | disclosed |
| CN-114222737-B | Small molecule inhibitors of NF- κB induced kinase | 詹森药业有限公司 | 2024-07-26 | — | — | CN | disclosed |
| EP-3976597-A1 | SMALL MOLECULE INHIBITORS OF NF-KB INDUCING KINASE | Janssen Pharmaceutica NV (BE) | 2022-04-06 | — | — | EP | disclosed |
| CN-114222737-A | Small molecule inhibitor of NF-kB induced kinase | 詹森药业有限公司 | 2022-03-22 | — | — | CN | disclosed |