Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 6/20 | 0.35 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 5/20 | 0.33 |
| ▸ | P2RX2 | Q9UBL9 | 3/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22715950 | 1.00 | PIK3CD (0.37) | PIK3CDRPS6KB1KDRIP6K1MAP4K4 | |
| SCHEMBL23870044 | 0.93 | IP6K1 (0.39) | PIK3CDRPS6KB1KDRIP6K1MAP4K4 | |
| SCHEMBL29439678 | 0.93 | IP6K1 (0.39) | PIK3CDRPS6KB1KDRIP6K1MAP4K4 | |
| SCHEMBL22715552 | 0.85 | P2RX3 (0.37) | PIK3CDP2RX3P2RX2PIK3CA | |
| SCHEMBL22744641 | 0.85 | PIK3CD (0.48) | PIK3CDKDRP2RX3P2RX2PDGFRB | |
| SCHEMBL29439864 | 0.85 | P2RX3 (0.37) | PIK3CDP2RX3P2RX2PIK3CA | |
| SCHEMBL22715558 | 0.85 | PIK3CD (0.37) | PIK3CDKDRP2RX3P2RX2PIK3CA | |
| SCHEMBL29439669 | 0.85 | PIK3CD (0.37) | PIK3CDKDRP2RX3P2RX2PIK3CA | |
| SCHEMBL22715668 | 0.80 | KDR (0.36) | KDRPDGFRB | |
| SCHEMBL29439762 | 0.80 | KDR (0.36) | KDRPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118908957-A | Small molecule inhibitors of NF- κB induced kinase | 詹森药业有限公司 | 2024-11-08 | — | — | CN | disclosed |
| CN-114222737-B | Small molecule inhibitors of NF- κB induced kinase | 詹森药业有限公司 | 2024-07-26 | — | — | CN | disclosed |
| EP-3976597-A1 | SMALL MOLECULE INHIBITORS OF NF-KB INDUCING KINASE | Janssen Pharmaceutica NV (BE) | 2022-04-06 | — | — | EP | disclosed |
| CN-114222737-A | Small molecule inhibitor of NF-kB induced kinase | 詹森药业有限公司 | 2022-03-22 | — | — | CN | disclosed |