Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of (+)-Taxifolin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.68 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.68 |
| ▸ | MAPT | P10636 | 3/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.68 |
| ▸ | RECQL | P46063 | 2/20 | 0.68 |
| ▸ | SOST | Q9BQB4 | 2/20 | 0.68 |
| ▸ | MEN1 | O00255 | 2/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.68 |
| ▸ | GAA | P10253 | 2/20 | 0.68 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.68 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.68 |
| ▸ | POLB | P06746 | 1/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.68 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.68 |
| ▸ | P4HB | P07237 | 1/20 | 0.55 |
| ▸ | XDH | P47989 | 2/20 | 0.53 |
| ▸ | SYNJ2 | O15056 | 3/20 | 0.53 |
| ▸ | APP | P05067 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30291877 | 0.92 | MAPT (0.62) | CYP3A4ALOX15MAPTHSD17B10RECQL | |
| SCHEMBL29638142 | 0.84 | CBS (0.56) | CYP3A4ALOX15MAPTHSD17B10RECQL | |
| SCHEMBL30915482 | 0.83 | CYP2C9 (0.58) | CYP3A4ALOX15MAPTHSD17B10RECQL | |
| SCHEMBL30915483 | 0.83 | CYP2C9 (0.58) | CYP3A4ALOX15MAPTHSD17B10RECQL | |
| (+)-Taxifolin SCHEMBL18131936 | 0.82 | CYP3A4 (0.90) | CYP3A4ALOX15MAPTHSD17B10RECQL | |
| (+)-Taxifolin SCHEMBL296323 | 0.82 | CYP3A4 (1.00) | CYP3A4ALOX15MAPTHSD17B10RECQL | |
| (+)-Taxifolin SCHEMBL13241264 | 0.82 | CYP3A4 (1.00) | CYP3A4ALOX15MAPTHSD17B10RECQL | |
| (+)-Taxifolin SCHEMBL1707803 | 0.82 | CYP3A4 (1.00) | CYP3A4ALOX15MAPTHSD17B10RECQL | |
| (+)-Taxifolin SCHEMBL7628142 | 0.82 | CYP3A4 (1.00) | CYP3A4ALOX15MAPTHSD17B10RECQL | |
| (+)-Epitaxifolin SCHEMBL31575455 | 0.82 | CYP3A4 (1.00) | CYP3A4ALOX15MAPTHSD17B10RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110441439-B | Metabolism marker for distinguishing taxus mairei and taxus yunnanensis and detection method thereof | 杭州师范大学 | 2022-03-01 | — | — | CN | disclosed |
| CN-110441439-B | Metabolism marker for distinguishing taxus mairei and taxus yunnanensis and detection method thereof | 杭州师范大学 | 2022-03-01 | — | — | CN | disclosed |