Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.51 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.51 |
| ▸ | MAPT | P10636 | 7/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | CA4 | P22748 | 2/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.48 |
| ▸ | CA6 | P23280 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29383556 | 0.89 | HSP90AB1 (0.59) | KDM4EMAPTRAB9AMEN1KMT2A | |
| SCHEMBL111675 | 0.89 | HSP90AB1 (0.59) | KDM4EMAPTRAB9AMEN1KMT2A | |
| Methane SCHEMBL28748613 | 0.87 | HSP90AB1 (0.57) | KDM4EMAPTRAB9AMEN1KMT2A | |
| Salicylic Acid SCHEMBL240023 | 0.79 | HPGD (0.78) | KDM4EMAPTMEN1KMT2AHPGD | |
| Salicylic Acid SCHEMBL27652523 | 0.79 | HPGD (0.78) | KDM4EMAPTMEN1KMT2AHPGD | |
| Salicylic Acid SCHEMBL7299833 | 0.79 | HPGD (0.78) | KDM4EMAPTMEN1KMT2AHPGD | |
| Salicylic Acid SCHEMBL240025 | 0.79 | HPGD (0.78) | KDM4EMAPTMEN1KMT2AHPGD | |
| SCHEMBL11982582 | 0.78 | HPGD (0.49) | KDM4EMAPTMEN1KMT2AHSP90AB1 | |
| SCHEMBL17641364 | 0.77 | SHBG (0.48) | KDM4EMAPTMEN1KMT2AHSP90AB1 | |
| SCHEMBL8644817 | 0.77 | MAPT (0.67) | KDM4EMAPTMEN1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114292297-A | Method for preparing antiviral drug tenofovir alafenamide fumarate | 福建南方制药股份有限公司 | 2022-04-08 | — | — | CN | claimed |
| CN-114292297-A | Method for preparing antiviral drug tenofovir alafenamide fumarate | 福建南方制药股份有限公司 | 2022-04-08 | — | — | CN | disclosed |