Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 2/20 | 0.41 |
| ▸ | DDR1 | Q08345 | 3/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22323772 | 1.00 | TNF (0.41) | TNFDDR1NFE2L2HDAC6ALDH1A1 | |
| SCHEMBL4781320 | 0.81 | HDAC6 (0.55) | TNFHDAC6MAPK1KMT2AHDAC3 | |
| SCHEMBL22101746 | 0.78 | LMNA (0.45) | DDR1HDAC6ALDH1A1MAPK1MCL1 | |
| SCHEMBL22323975 | 0.78 | HDAC6 (0.44) | TNFDDR1NFE2L2HDAC6MCL1 | |
| SCHEMBL29447081 | 0.78 | HDAC6 (0.44) | TNFDDR1NFE2L2HDAC6MCL1 | |
| SCHEMBL22323977 | 0.74 | L3MBTL1 (0.46) | TNFHDAC6ALDH1A1L3MBTL1 | |
| SCHEMBL29447086 | 0.74 | L3MBTL1 (0.46) | TNFHDAC6ALDH1A1L3MBTL1 | |
| SCHEMBL22101195 | 0.72 | ALDH1A1 (0.44) | TNFHDAC6ALDH1A1MAPK1LMNA | |
| SCHEMBL15680582 | 0.72 | TNF (0.60) | TNFHDAC6ALDH1A1MCL1LMNA | |
| SCHEMBL15228456 | 0.71 | SMN1; SMN2 (0.55) | ALDH1A1LMNAMAPTKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114126613-A | Methods and compositions for modulating splicing | 斯基霍克疗法公司 | 2022-03-01 | — | — | CN | disclosed |