Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MITF | O75030 | 9/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.50 |
| ▸ | HTT | P42858 | 8/20 | 0.50 |
| ▸ | NPC1 | O15118 | 7/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.50 |
| ▸ | RAB9A | P51151 | 9/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | S1PR4 | O95977 | 5/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 4/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.44 |
| ▸ | KMO | O15229 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29452222 | 0.83 | MEN1 (0.48) | MITFALDH1A1HTTNPC1SMN1; SMN2 | |
| SCHEMBL29451310 | 0.80 | ALDH1A1 (0.53) | MITFALDH1A1HTTNPC1SMN1; SMN2 | |
| SCHEMBL2888078 | 0.80 | HTT (0.69) | MITFALDH1A1HTTNPC1SMN1; SMN2 | |
| SCHEMBL15484968 | 0.76 | ALDH1A1 (0.51) | MITFALDH1A1HTTNPC1SMN1; SMN2 | |
| SCHEMBL23122130 | 0.76 | NPC1 (0.46) | MITFALDH1A1HTTNPC1SMN1; SMN2 | |
| SCHEMBL29451307 | 0.75 | ALDH1A1 (0.48) | MITFALDH1A1HTTNPC1SMN1; SMN2 | |
| SCHEMBL29102671 | 0.75 | NPBWR1 (0.68) | MITFALDH1A1HTTSMN1; SMN2RAB9A | |
| SCHEMBL29451571 | 0.74 | HTT (0.47) | MITFALDH1A1HTTNPC1SMN1; SMN2 | |
| SCHEMBL29451575 | 0.74 | ALDH1A1 (0.47) | MITFALDH1A1HTTNPC1SMN1; SMN2 | |
| SCHEMBL29451930 | 0.73 | ALDH1A1 (0.46) | MITFALDH1A1HTTNPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032144-A1 | SUBSTRATE ADAPTOR INHIBITORS OF PRMT5 AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2022-02-10 | — | — | WO | disclosed |