Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 7/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 7/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 7/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 7/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 7/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 7/20 | 0.35 |
| ▸ | GABRA4 | P48169 | 7/20 | 0.35 |
| ▸ | GABRA6 | Q16445 | 7/20 | 0.35 |
| ▸ | GABRP | O00591 | 6/20 | 0.35 |
| ▸ | GABRD | O14764 | 6/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 6/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 6/20 | 0.35 |
| ▸ | GABRE | P78334 | 6/20 | 0.35 |
| ▸ | GABRG1 | Q8N1C3 | 6/20 | 0.35 |
| ▸ | GABRG3 | Q99928 | 6/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2945832 | 0.89 | KDM4E (0.36) | KDM4EALDH1A1HPGDHSD17B10CNR2 | |
| SCHEMBL2945330 | 0.87 | MAP3K5 (0.35) | KMT2AMAP3K5 | |
| SCHEMBL2951250 | 0.85 | POLB (0.38) | KDM4EALDH1A1HPGDHSD17B10CNR2 | |
| SCHEMBL2943196 | 0.83 | LMNA (0.41) | KDM4EALDH1A1HPGDHSD17B10CNR2 | |
| SCHEMBL2946990 | 0.81 | GABRA1 (0.46) | KDM4EALDH1A1HPGDHSD17B10CNR2 | |
| SCHEMBL2945079 | 0.80 | ALOX5 (0.39) | KDM4EALDH1A1CNR2GABRA1GABRG2 | |
| SCHEMBL2951309 | 0.80 | GABRA1 (0.41) | KDM4EALDH1A1HPGDHSD17B10CNR2 | |
| SCHEMBL2947275 | 0.79 | KDM4E (0.40) | KDM4EALDH1A1HPGDHSD17B10CNR2 | |
| SCHEMBL4906425 | 0.79 | NPC1 (0.38) | KDM4EALDH1A1HPGDHSD17B10GABRA1 | |
| SCHEMBL2947278 | 0.78 | GABRA1 (0.40) | KDM4EALDH1A1HPGDHSD17B10CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1558611-B1 | HIV-INTEGRASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS FOR THEIR USE | PFIZER (US) | 2010-01-06 | — | — | EP | disclosed |
| US-20080221154-A1 | HIV-INTEGRASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS FOR THEIR USE | PFIZER INC | 2008-09-11 | — | — | US | disclosed |
| US-7368571-B2 | HIV-Integrase inhibitors, pharmaceutical compositions and methods for their use | PFIZER INC (US) | 2008-05-06 | — | — | US | disclosed |
| US-20070004768-A1 | HIV-INTEGRASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR THEIR USE | AGOURON PHARMACEUTICALS, INC. | 2007-01-04 | — | — | US | disclosed |
| US-7135482-B2 | HIV-integrase inhibitors, pharmaceutical compositions, and methods for their use | AGOURON PHARMACEUTICALS, INC. (US) | 2006-11-14 | — | — | US | disclosed |
| US-20040147547-A1 | HIV-integrase inhibitors, pharmaceutical compositions, and methods for their use | AGOURON PHARMACEUTICALS, INC. | 2004-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040147547-A1 | HIV-integrase inhibitors, pharmaceutical compositions, and methods for their use | IMPDH1, POLA1, POLB | KDM4E 1173/4885ALDH1A1 794/4885HPGD 185/4885 |
| US-20070004768-A1 | HIV-INTEGRASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR THEIR USE | TYMP, IMPDH1, POLB | KDM4E 1098/4885ALDH1A1 1133/4885HPGD 107/4885 |
| US-20080221154-A1 | HIV-INTEGRASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS FOR THEIR USE | TYMP, IMPDH1, POLB | KDM4E 1001/4885ALDH1A1 1208/4885HPGD 124/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.