Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 11/20 | 0.58 |
| ▸ | MITF | O75030 | 8/20 | 0.58 |
| ▸ | NPC1 | O15118 | 5/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.58 |
| ▸ | HTT | P42858 | 5/20 | 0.58 |
| ▸ | PAX8 | Q06710 | 6/20 | 0.54 |
| ▸ | PRMT5 | O14744 | 7/20 | 0.51 |
| ▸ | WDR77 | Q9BQA1 | 7/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | MAPT | P10636 | 6/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | S1PR4 | O95977 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.51 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.51 |
| ▸ | RIOK1 | Q9BRS2 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29451432 | 0.88 | RAB9A (0.58) | RAB9AMITFNPC1NPSR1HTT | |
| SCHEMBL29451793 | 0.85 | RAB9A (0.61) | RAB9AMITFNPC1NPSR1HTT | |
| SCHEMBL29452154 | 0.70 | MITF (1.00) | RAB9AMITFNPC1HTTPAX8 | |
| SCHEMBL29451943 | 0.70 | RAB9A (0.53) | RAB9AMITFNPC1NPSR1HTT | |
| SCHEMBL29451608 | 0.70 | RAB9A (0.76) | RAB9AMITFNPC1NPSR1HTT | |
| SCHEMBL29452083 | 0.69 | PRMT5 (0.74) | RAB9AMITFNPC1NPSR1HTT | |
| SCHEMBL29451409 | 0.69 | PRMT5 (0.68) | RAB9AMITFNPC1NPSR1HTT | |
| SCHEMBL29452248 | 0.67 | ALDH1A1 (0.64) | RAB9AMITFNPC1NPSR1HTT | |
| SCHEMBL24511913 | 0.67 | GAA (0.67) | HTTALDH1A1MAPTL3MBTL1KMT2A | |
| SCHEMBL30591094 | 0.67 | GAA (0.67) | HTTALDH1A1MAPTL3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032144-A1 | SUBSTRATE ADAPTOR INHIBITORS OF PRMT5 AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2022-02-10 | — | — | WO | disclosed |