Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 4/20 | 0.37 |
| ▸ | FEN1 | P39748 | 4/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.35 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31195184 | 0.76 | ALDH1A1 (0.43) | ALDH1A1ALOX5APFEN1PDE2APDE5A | |
| SCHEMBL29451494 | 0.73 | ALDH1A1 (0.59) | ALDH1A1TSHRPDE2APDE5ACYP3A4 | |
| SCHEMBL12352542 | 0.71 | ALDH1A1 (0.47) | ALDH1A1TSHRMAPTCYP3A4MEN1 | |
| SCHEMBL7537342 | 0.70 | ALDH1A1 (0.56) | ALDH1A1PDE2APDE5ACYP3A4ALOX15 | |
| SCHEMBL29451752 | 0.70 | ALDH1A1 (0.56) | ALDH1A1PDE2APDE5ACYP3A4ALOX15 | |
| SCHEMBL2663819 | 0.69 | ALDH1A1 (0.41) | ALDH1A1ALOX5APFEN1TSHRMAPT | |
| SCHEMBL16364899 | 0.68 | ALDH1A1 (0.55) | ALDH1A1TSHRPDE2APDE5ACYP3A4 | |
| SCHEMBL9646971 | 0.67 | ALDH1A1 (0.41) | ALDH1A1ALOX5APFEN1TSHRMAPT | |
| SCHEMBL11394393 | 0.67 | ALDH1A1 (0.41) | ALDH1A1ALOX5APFEN1TSHRMAPT | |
| SCHEMBL4639725 | 0.67 | L3MBTL1 (0.63) | ALDH1A1ALOX5APFEN1TSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032144-A1 | SUBSTRATE ADAPTOR INHIBITORS OF PRMT5 AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2022-02-10 | — | — | WO | disclosed |