Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
| ▸ | HPGD | P15428 | 2/20 | 0.69 |
| ▸ | POLB | P06746 | 2/20 | 0.66 |
| ▸ | MAPT | P10636 | 2/20 | 0.66 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.52 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10126597 | 1.00 | ALDH1A1 (0.69) | ALDH1A1KMT2AMEN1HPGDPOLB | |
| SCHEMBL10126582 | 0.89 | MAPT (0.70) | ALDH1A1KMT2AMEN1HPGDPOLB | |
| SCHEMBL17979825 | 0.87 | L3MBTL1 (0.59) | ALDH1A1KMT2AMEN1HPGDPOLB | |
| SCHEMBL17979844 | 0.86 | SMN1; SMN2 (0.70) | ALDH1A1KMT2AMAPTLMNASMN1; SMN2 | |
| SCHEMBL22767393 | 0.83 | SMN1; SMN2 (0.72) | ALDH1A1KMT2AMEN1HPGDPOLB | |
| SCHEMBL3911491 | 0.82 | POLB (0.68) | ALDH1A1KMT2AMEN1HPGDPOLB | |
| SCHEMBL22767345 | 0.81 | LMNA (0.74) | ALDH1A1KMT2AMEN1HPGDPOLB | |
| SCHEMBL3911494 | 0.80 | MAPT (0.70) | ALDH1A1KMT2AMEN1HPGDPOLB | |
| SCHEMBL4029063 | 0.80 | MAPT (0.70) | ALDH1A1KMT2AMEN1HPGDPOLB | |
| SCHEMBL3181603 | 0.80 | POLB (0.65) | ALDH1A1KMT2AMEN1HPGDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032144-A1 | SUBSTRATE ADAPTOR INHIBITORS OF PRMT5 AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2022-02-10 | — | — | WO | disclosed |