Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 8/20 | 0.45 |
| ▸ | WDR77 | Q9BQA1 | 8/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | MITF | O75030 | 2/20 | 0.34 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.34 |
| ▸ | RIOK1 | Q9BRS2 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29451727 | 1.00 | PRMT5 (0.45) | PRMT5WDR77NPC1RAB9AMITF | |
| SCHEMBL29451540 | 0.86 | FPR1 (0.35) | PRMT5WDR77NPC1RAB9ARIOK1 | |
| SCHEMBL29452153 | 0.83 | PRMT5 (0.35) | PRMT5WDR77NPC1RAB9ARIOK1 | |
| SCHEMBL29451404 | 0.80 | RAB9A (0.55) | PRMT5WDR77NPC1RAB9AMITF | |
| SCHEMBL29451915 | 0.75 | PRMT5 (0.46) | PRMT5WDR77NPC1RAB9AMITF | |
| SCHEMBL29452187 | 0.75 | PRMT5 (0.46) | PRMT5WDR77NPC1RAB9AMITF | |
| SCHEMBL29451308 | 0.75 | RAB9A (0.57) | PRMT5WDR77NPC1RAB9AMITF | |
| SCHEMBL29451807 | 0.70 | PRMT5 (0.67) | PRMT5WDR77NPC1RAB9AMITF | |
| SCHEMBL29452171 | 0.70 | PRMT5 (0.71) | PRMT5WDR77NPC1RAB9AMITF | |
| SCHEMBL14501195 | 0.63 | HTT (0.44) | PRMT5WDR77NPC1RAB9AMITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032144-A1 | SUBSTRATE ADAPTOR INHIBITORS OF PRMT5 AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2022-02-10 | — | — | WO | disclosed |