Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR1 | P21462 | 3/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 4/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 4/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | RIOK1 | Q9BRS2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29452153 | 0.87 | PRMT5 (0.35) | FPR1PRMT5WDR77MMP2MMP9 | |
| SCHEMBL29452230 | 0.86 | PRMT5 (0.45) | PRMT5WDR77MMP2MMP9RAB9A | |
| SCHEMBL29451727 | 0.86 | PRMT5 (0.45) | PRMT5WDR77MMP2MMP9RAB9A | |
| SCHEMBL29452047 | 0.81 | PRMT5 (0.47) | PRMT5WDR77RAB9ANPC1MAPT | |
| SCHEMBL29451823 | 0.76 | KDM4E (0.40) | FPR1PRMT5WDR77RAB9ANPC1 | |
| SCHEMBL29451784 | 0.71 | PRMT5 (0.44) | PRMT5WDR77RAB9ANPC1MAPT | |
| SCHEMBL29451728 | 0.70 | KCNJ6 (0.52) | PRMT5WDR77RAB9ANPC1KDM4E | |
| SCHEMBL29451404 | 0.68 | RAB9A (0.55) | PRMT5WDR77RAB9ANPC1MAPT | |
| SCHEMBL29451708 | 0.64 | ALDH1A1 (0.46) | RAB9APOLBKDM4E | |
| SCHEMBL29451586 | 0.59 | ABCC8 (0.44) | MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032144-A1 | SUBSTRATE ADAPTOR INHIBITORS OF PRMT5 AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2022-02-10 | — | — | WO | disclosed |