SCHEMBL29453036

SCHEMBL29453036

O=C(NCCO)c1cccc(-c2cc(Nc3ccc(OC(F)(F)F)cc3)ncn2)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
ABL1 P00519 20/20 1.00
BCR P11274 18/20 1.00
KDM4E B2RXH2 1/20 0.72
MAPT P10636 1/20 0.72
MAPK1 P28482 1/20 0.72

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL924071 1.00 ABL1 (1.00) ABL1BCRKDM4EMAPTMAPK1
SCHEMBL25735738 0.93 ABL1 (0.86) ABL1BCRKDM4EMAPTMAPK1
SCHEMBL25824263 0.90 ABL1 (0.82) ABL1BCRKDM4EMAPTMAPK1
SCHEMBL3902519 0.89 ABL1 (0.80) ABL1BCRKDM4EMAPTMAPK1
SCHEMBL16898587 0.88 ABL1 (0.79) ABL1BCRKDM4EMAPTMAPK1
SCHEMBL16898190 0.88 ABL1 (0.78) ABL1BCRKDM4EMAPTMAPK1
SCHEMBL16898602 0.88 ABL1 (0.78) ABL1BCRKDM4EMAPTMAPK1
SCHEMBL16898654 0.88 ABL1 (0.78) ABL1BCRKDM4EMAPTMAPK1
SCHEMBL16898548 0.87 ABL1 (0.77) ABL1BCRKDM4EMAPTMAPK1
SCHEMBL16898299 0.87 ABL1 (0.77) ABL1BCRKDM4EMAPTMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 90 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12419891-B2 Compositions for the treatment of pathogenic- and/or chemical-induced lung injury and for the treatment of cancer and methods of using same DUKE UNIVERSITY (US) 2025-09-23 US claimed
WO-2025007166-A1 BCR-ABL INHIBITORS FOR USE IN TREATING KELOID DISEASE UNIVERSITY OF CAPE TOWN (ZA) 2025-01-02 WO claimed
US-20240390370-A1 Compositions for the Treatment of Pathogenic- And/Or Chemical-Induced Lung Injury and for the Treatment of Cancer and Methods of Using Same DUKE UNIVERSITY 2024-11-28 US claimed
US-12104168-B2 Cell culture medium AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (A*STAR) (SG) 2024-10-01 US claimed
US-20240156816-A1 METHODS AND COMPOSITIONS FOR PREDICTING AND PREVENTING RELAPSE OF ACUTE LYMPHOBLASTIC LEUKEMIA DANA-FARBER CANCER INSTITUTE, INC. 2024-05-16 US claimed
CN-113786409-B Compositions comprising phosphoinositide 3-kinase inhibitors and a second antiproliferative agent 甫康(上海)健康科技有限责任公司 2024-04-02 CN claimed
US-20240058335-A1 METHODS FOR TREATMENT OF CANCER USING ABL INHIBITORS AND DRUGS TARGETING THE MEVALONATE PATHWAY DUKE UNIVERSITY (US) 2024-02-22 US claimed
US-11883401-B2 Compositions for the treatment of pathogenic- and/or chemical-induced lung injury and for the treatment of cancer and methods of using same DUKE UNIVERSITY (US) 2024-01-30 US claimed
US-11844800-B2 Methods and compositions for predicting and preventing relapse of acute lymphoblastic leukemia MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2023-12-19 US claimed
EP-3337477-B1 COMPOSITIONS COMPRISING PHOSPHOINOSITIDE 3-KINASE INHIBITORS AND A SECOND ANTIPROLIFERATIVE AGENT CONVALIFE SHANGHAI CO LTD (CN) 2023-02-01 EP claimed
US-20260109694-A1 HETEROCYCLIC COMPOUNDS AND USES THEREOF KUMQUAT BIOSCIENCES INC (US) 2026-04-23 US disclosed
EP-4720059-A1 HETEROCYCLIC COMPOUNDS AND USES THEREOF Kumquat Biosciences Inc. (US) 2026-04-08 EP disclosed
US-12551555-B2 Compositions and methods for potentiating immune activity KUMQUAT BIOSCIENCES INC. (US) 2026-02-17 US disclosed
US-12503464-B2 1,2,5-thiadiazolidin-3-one 1,1-dioxide containing compounds and uses thereof KUMQUAT BIOSCIENCES INC. (US) 2025-12-23 US disclosed
EP-4658317-A1 PROGRAMMABLE DNA PROTEOLYSIS TARGET CHIMERAS AND METHODS OF THEIR USE Arizona Board of Regents on behalf of Arizona State University (US) 2025-12-10 EP disclosed
WO-2022165185-A1 CANCER-SELECTIVE TARGET DEGRADATION BY TARGETING GROUP CAGED PROTACS BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (US) 2022-08-04 WO disclosed
US-20220170109-A1 PURITY INDEPENDENT SUBTYPING OF TUMORS (PURIST), A PLATFORM AND SAMPLE TYPE INDEPENDENT SINGLE SAMPLE CLASSIFIER FOR TREATMENT DECISION MAKING IN PANCREATIC CANCER THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2022-06-02 US disclosed
US-11324827-B2 Multifunctionalized polyethylene glycol derivative and preparation method therefor XIAMEN SINOPEG BIOTECH CO., LTD. (CN) 2022-05-10 US disclosed
US-11291669-B2 Compositions comprising phosphoinositide 3-kinase inhibitors and a second antiproliferative agent KARUS THERAPEUTICS LIMITED (GB) 2022-04-05 US disclosed
CN-108379591-B Synthesis of immune agonist targeting compound and application thereof 深圳大学 2022-03-29 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11883401-B2 Compositions for the treatment of pathogenic- and/or chemical-induced lung injury and for the treatment of cancer and methods of using same DDIT3, MCL1, MYD88 ABL1 938/4885BCR 445/4885KDM4E 4383/4885
US-20260109694-A1 HETEROCYCLIC COMPOUNDS AND USES THEREOF CCR10, SLC11A2, MSR1 ABL1 3589/4885BCR 417/4885KDM4E 4595/4885
US-20240058335-A1 METHODS FOR TREATMENT OF CANCER USING ABL INHIBITORS AND DRUGS TARGETING THE MEVALONATE PATHWAY ABL2, ABL1, VAV1 ABL1 2/4885BCR 6/4885KDM4E 996/4885
US-12551555-B2 Compositions and methods for potentiating immune activity PTPRCAP, PTPN2, PTPRC ABL1 296/4885BCR 59/4885KDM4E 2917/4885
US-20240390370-A1 Compositions for the Treatment of Pathogenic- And/Or Chemical-Induced Lung Injury and for the Treatment of Cancer and Methods of Using Same DDIT3, MCL1, MYD88 ABL1 938/4885BCR 445/4885KDM4E 4383/4885
US-12503464-B2 1,2,5-thiadiazolidin-3-one 1,1-dioxide containing compounds and uses thereof BRCA1, STING1, IFNG ABL1 539/4885BCR 1890/4885KDM4E 2812/4885
US-11291669-B2 Compositions comprising phosphoinositide 3-kinase inhibitors and a second antiproliferative agent MCL1, MYC, XIAP ABL1 913/4885BCR 510/4885KDM4E 1556/4885
US-12419891-B2 Compositions for the treatment of pathogenic- and/or chemical-induced lung injury and for the treatment of cancer and methods of using same DDIT3, MCL1, MYD88 ABL1 938/4885BCR 445/4885KDM4E 4383/4885
US-11324827-B2 Multifunctionalized polyethylene glycol derivative and preparation method therefor HDGF, F11, F12 ABL1 3984/4885BCR 1671/4885KDM4E 4115/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.