Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5240562 | 0.89 | PDE10A (0.41) | PDE10ANPC1RAB9ARXFP1HRH3 | |
| SCHEMBL13236492 | 0.88 | RAB9A (0.46) | PDE10ANPC1RAB9ARXFP1HRH3 | |
| SCHEMBL2953031 | 0.84 | NPC1 (0.51) | PDE10ANPC1RAB9ARXFP1HRH3 | |
| SCHEMBL15473552 | 0.81 | PDE10A (0.40) | PDE10AHRH3 | |
| SCHEMBL2952526 | 0.78 | NPC1 (0.43) | NPC1RAB9ARXFP1HRH3KDM4E | |
| SCHEMBL13236502 | 0.77 | KDM1A (0.35) | — | |
| SCHEMBL2952528 | 0.74 | NPC1 (0.47) | PDE10ANPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL15473558 | 0.74 | PDE10A (0.43) | PDE10ANPC1RAB9ARXFP1KDR | |
| SCHEMBL2946483 | 0.74 | HRH3 (0.47) | NPC1RAB9AHRH3KDM4EALDH1A1 | |
| SCHEMBL2947288 | 0.73 | RXFP1 (0.48) | NPC1RAB9ARXFP1HRH3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7759349-B2 | Control of parasites in animals by the use of imidazo[1,2-b]pyridazine derivatives | SCHERING-PLOUGH ANIMAL HEALTH CORPORATION (US) | 2010-07-20 | — | — | US | disclosed |
| US-7759349-B2 | Control of parasites in animals by the use of imidazo[1,2-b]pyridazine derivatives | SCHERING-PLOUGH ANIMAL HEALTH CORPORATION (US) | 2010-07-20 | — | — | US | disclosed |
| US-7759349-B2 | Control of parasites in animals by the use of imidazo[1,2-b]pyridazine derivatives | SCHERING-PLOUGH ANIMAL HEALTH CORPORATION (US) | 2010-07-20 | — | — | US | disclosed |
| EP-1699799-B1 | CONTROL OF PARASITES IN ANIMALS BY THE USE OF IMIDAZO [1,2-B]PYRIDAZINE DERIVATIVES | SCHERING PLOUGH LTD (CH) | 2007-05-16 | — | — | EP | disclosed |
| EP-1699799-A1 | CONTROL OF PARASITES IN ANIMALS BY THE USE OF IMIDAZO [1,2-B]PYRIDAZINE DERIVATIVES | Schering-Plough Ltd. (CH) | 2006-09-13 | — | — | EP | disclosed |
| US-20050182059-A1 | Control of parasites in animals by the use of imidazo[1,2-b]pyridazine derivatives | SCHERING-PLOUGH ANIMAL HEALTH CORPORATION | 2005-08-18 | — | — | US | disclosed |
| WO-2005066177-A1 | CONTROL OF PARASITES IN ANIMALS BY THE USE OF IMIDAZO[1,2-B]PYRIDAZINE DERIVATIVES | SCHERING-PLOUGH LTD. (CH) | 2005-07-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050182059-A1 | Control of parasites in animals by the use of imidazo[1,2-b]pyridazine derivatives | PLPBP, PIR, PPIP5K2 | PDE10A 3871/4885NPC1 4114/4885RAB9A 1319/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.