SCHEMBL29454228

SCHEMBL29454228

Cc1cc(N)c(Cl)c(Nc2ccc(F)cc2F)c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SOS1 Q07889 1/20 0.39
ALDH1A1 P00352 4/20 0.39
GAA P10253 5/20 0.37
MEN1 O00255 4/20 0.37
KMT2A Q03164 4/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
AKT1 P31749 1/20 0.37
POLB P06746 1/20 0.37
MAPT P10636 1/20 0.37
ALOX12 P18054 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
NPC1 O15118 3/20 0.36
RAB9A P51151 3/20 0.36
CYP2D6 P10635 1/20 0.36
CYP2C19 P33261 1/20 0.36
MAPK1 P28482 1/20 0.36
HTT P42858 1/20 0.36
KDM4E B2RXH2 1/20 0.35
NFKB1 P19838 1/20 0.35
NFKB2 Q00653 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31723198 1.00 SOS1 (0.39) SOS1ALDH1A1GAAMEN1KMT2A
SCHEMBL22231787 1.00 SOS1 (0.39) SOS1ALDH1A1GAAMEN1KMT2A
SCHEMBL22231933 0.88 NUDT1 (0.40) KMT2AMAPTTDP1
SCHEMBL31723200 0.88 NUDT1 (0.40) KMT2AMAPTTDP1
SCHEMBL29454149 0.88 NUDT1 (0.40) KMT2AMAPTTDP1
SCHEMBL22232061 0.83 SLC6A4 (0.38) GAAMEN1KMT2AAKT1POLB
SCHEMBL29454105 0.83 SLC6A4 (0.38) GAAMEN1KMT2AAKT1POLB
SCHEMBL31723243 0.83 SLC6A4 (0.38) GAAMEN1KMT2AAKT1POLB
SCHEMBL22231721 0.81 BPTF (0.41) SOS1ALDH1A1GAAMEN1KMT2A
SCHEMBL29454349 0.81 BPTF (0.41) SOS1ALDH1A1GAAMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12545639-B2 3-substituted phenylamidine compounds, preparation and use thereof PI INDUSTRIES LTD. (IN) 2026-02-10 US claimed
US-20220089523-A1 3-SUBSTITUTED PHENYLAMIDINE COMPOUNDS, PREPARATION AND USE THEREOF PI INDUSTRIES LTD. (IN) 2022-03-24 US claimed
US-12545639-B2 3-substituted phenylamidine compounds, preparation and use thereof PI INDUSTRIES LTD. (IN) 2026-02-10 US disclosed
EP-4647426-A2 3-SUBSTITUTED PHENYLAMIDINE COMPOUNDS, PREPARATION AND USE THEREOF PI Industries Ltd. (IN) 2025-11-12 EP disclosed
US-20220089523-A1 3-SUBSTITUTED PHENYLAMIDINE COMPOUNDS, PREPARATION AND USE THEREOF PI INDUSTRIES LTD. (IN) 2022-03-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220089523-A1 3-SUBSTITUTED PHENYLAMIDINE COMPOUNDS, PREPARATION AND USE THEREOF H1-3, PRMT7, PFAS SOS1 4850/4885ALDH1A1 1020/4885GAA 1080/4885
US-12545639-B2 3-substituted phenylamidine compounds, preparation and use thereof CBR1, CBR3, HCCS SOS1 3250/4885ALDH1A1 2035/4885GAA 2001/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.