Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29454267 | 0.79 | NPC1 (0.52) | NPC1RAB9ANPSR1ALDH1A1CYP1A2 | |
| SCHEMBL7142190 | 0.79 | NPC1 (0.52) | NPC1RAB9ANPSR1ALDH1A1CYP1A2 | |
| SCHEMBL22069015 | 0.79 | NPC1 (0.52) | NPC1RAB9ANPSR1ALDH1A1CYP1A2 | |
| SCHEMBL28860755 | 0.78 | NPC1 (0.56) | NPC1RAB9ANPSR1ALDH1A1CYP1A2 | |
| SCHEMBL1897287 | 0.77 | NPC1 (0.69) | NPC1RAB9ANPSR1ALDH1A1CYP1A2 | |
| SCHEMBL22069331 | 0.77 | NPC1 (0.50) | NPC1RAB9ANPSR1ALDH1A1CYP1A2 | |
| SCHEMBL17868187 | 0.76 | NPC1 (0.44) | NPC1RAB9ANPSR1ALDH1A1CYP1A2 | |
| SCHEMBL29739678 | 0.75 | NPC1 (0.48) | NPC1RAB9ANPSR1ALDH1A1CYP1A2 | |
| SCHEMBL10356846 | 0.75 | RAB9A (0.81) | NPC1RAB9ANPSR1ALDH1A1CYP1A2 | |
| SCHEMBL8103369 | 0.74 | GAA (0.58) | NPC1RAB9ANPSR1ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220323455-A1 | FUSED HETEROCYCLIC DERIVATIVES AS ANTIVIRAL AGENTS | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2022-10-13 | — | — | US | disclosed |
| US-20220235051-A1 | DI-FLUORO AZEPANES AS HBV CAPSID ASSEMBLY MODULATORS | JANSSEN SCIENCES IRELAND UNLMITED COMPANY (IE) | 2022-07-28 | — | — | US | disclosed |
| EP-3976616-A1 | FUSED HETEROCYCLIC DERIVATIVES AS ANTIVIRAL AGENTS | Janssen Sciences Ireland Unlimited Company (IE) | 2022-04-06 | — | — | EP | disclosed |
| EP-3976614-A1 | DI-FLUORO AZEPANES AS HBV CAPSID ASSEMBLY MODULATORS | Janssen Sciences Ireland Unlimited Company (IE) | 2022-04-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220235051-A1 | DI-FLUORO AZEPANES AS HBV CAPSID ASSEMBLY MODULATORS | CALM1, HAVCR2, ZC3HAV1 | NPC1 950/4885RAB9A 2021/4885NPSR1 4045/4885 |
| US-20220323455-A1 | FUSED HETEROCYCLIC DERIVATIVES AS ANTIVIRAL AGENTS | HAVCR2, MAVS, ZC3HAV1 | NPC1 414/4885RAB9A 487/4885NPSR1 4535/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.