SCHEMBL29454464

SCHEMBL29454464

COc1ccc(CN(CC(=O)O)C(=O)C(CC(=O)OC(C)(C)C)NC(=O)OCC2c3ccccc3-c3ccccc32)c(O)c1

nearest known ligand 0.40

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ MDM2 Q00987 3/20 0.40
▸ PTPN1 P18031 1/20 0.40
▸ MDM4 O15151 3/20 0.39
▸ TP53 P04637 3/20 0.39
▸ SLC17A5 Q9NRA2 1/20 0.39
▸ CASP3 P42574 3/20 0.39
▸ CACNA1B Q00975 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29406617 0.93 MDM2 (0.40) MDM2MDM4TP53CASP3CACNA1B
SCHEMBL29398142 0.88 POLB (0.34) MDM2PTPN1CASP3
SCHEMBL30057700 0.81 MDM2 (0.40) MDM2MDM4TP53SLC17A5CASP3
SCHEMBL18429453 0.80 CASP3 (0.47) MDM2MDM4TP53CASP3
SCHEMBL29462650 0.79 PTPN1 (0.46) MDM2PTPN1MDM4TP53CASP3
SCHEMBL29401351 0.79 POLB (0.43) PTPN1
SCHEMBL24579398 0.77 CASP3 (0.46) MDM2MDM4TP53CASP3
SCHEMBL29696746 0.77 CASP3 (0.46) MDM2MDM4TP53CASP3
SCHEMBL26126637 0.77 CASP3 (0.46) MDM2MDM4TP53CASP3
SCHEMBL5491568 0.76 JAK3 (0.44) MDM2MDM4TP53CASP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3724215-B1 PEPTIDOMIMETICS, METHOD OF SYNTHESIS AND USES THEREOF PASTEUR INSTITUT (FR) 2022-04-13 — — EP claimed
US-20230288411-A1 POLYPEPTIDE, MULTIMER, SOLID PHASE, MEASUREMENT METHOD FOR TEST SUBSTANCE, AND REAGENT KIT SYSMEX CORPORATION (JP) 2023-09-14 — — US disclosed
EP-4230643-A1 POLYPEPTIDE, POLYMER, SOLID PHASE, MEASUREMENT METHOD FOR TEST SUBSTANCE, AND REAGENT KIT SYSMEX CORPORATION (JP) 2023-08-23 — — EP disclosed
CN-116348498-A Method and kit for determining polypeptide, polymer, solid phase and test substance 希森美康株式会社 2023-06-27 — — CN disclosed
US-11472844-B2 Peptidomimetics, method of synthesis and uses thereof CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2022-10-18 — — US disclosed
WO-2022080486-A1 POLYPEPTIDE, POLYMER, SOLID PHASE, MEASUREMENT METHOD FOR TEST SUBSTANCE, AND REAGENT KIT シスメックス株式会社 2022-04-21 — — WO disclosed
EP-3724215-B1 PEPTIDOMIMETICS, METHOD OF SYNTHESIS AND USES THEREOF PASTEUR INSTITUT (FR) 2022-04-13 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230288411-A1 POLYPEPTIDE, MULTIMER, SOLID PHASE, MEASUREMENT METHOD FOR TEST SUBSTANCE, AND REAGENT KIT BTD, DNPEP, GC MDM2 1641/4885PTPN1 4519/4885MDM4 2095/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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