GC

Vitamin D-binding protein · P02774 · GC on Sugi Atlas →

4,578 patent compounds predicted against GC, 4,186 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Calcitriol (SCHEMBL3245)	1.00	1/20
Calcitriol (SCHEMBL3603)	1.00	1/20
Calcitriol (SCHEMBL39703)	1.00	1/20
Calcitriol (SCHEMBL39704)	1.00	1/20
Calcitriol (SCHEMBL93587)	1.00	1/20
Calcitriol (SCHEMBL1399709)	1.00	1/20
Calcitriol (SCHEMBL2641696)	1.00	1/20
Calcitriol (SCHEMBL2733051)	1.00	1/20
Calcitriol (SCHEMBL2867274)	1.00	1/20
Calcitriol (SCHEMBL3488822)	1.00	1/20
Calcitriol (SCHEMBL3329859)	0.98	1/20
Calcitriol (SCHEMBL3329862)	0.98	1/20
Calcitriol (SCHEMBL4934419)	0.98	1/20
Calcitriol (SCHEMBL4934421)	0.98	1/20
Calcitriol (SCHEMBL3894035)	0.93	1/20
Calcitriol (SCHEMBL5052699)	0.93	1/20
Calcitriol (SCHEMBL2229150)	0.89	1/20
Calcitriol (SCHEMBL1820419)	0.88	1/20
Ercalcitriol (SCHEMBL3053847)	0.86	1/20
SCHEMBL3730158	0.86	1/20

Clinical trials — most relevant to GC by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
REstoration of VItamin D in Pulmonary Arterial Hypertension	PHASE4	NOT_YET_RECRUITING
Investigating the Effects of Hydroxyvitamin D3 on Multiple Sclerosis	PHASE4	UNKNOWN
Effect of Single High Dose of Cholecalciferol on Serum Metabolites of Vitamin D	PHASE4	COMPLETED
Vitamin D Status in Patients With Severe Sepsis	PHASE3	WITHDRAWN
High-dose Vitamin D Supplement for the Prevention of Acute Asthma-like Symptoms in Preschool Children	PHASE2	RECRUITING
Safety, Tolerability and Efficacy of GcMAF in Patients With Chronic Inflammatory Diseases	PHASE1/PHASE2	COMPLETED
Efficacy and Safety of Oral Immunotherapy With GcMAF in Hospitalized Patients With COVID-19 Pneumonia	PHASE2	COMPLETED
Vitamin D Dose-Response Study to Establish Dietary Requirements in Infants	PHASE2	COMPLETED
Vitamin D Binding Protein (Gc) Allele Variation Effects Response to Vitamin D Treatment	nan	COMPLETED
Isolation of Vitamin D Binding Protein Isoforms From Human Volunteers	nan	ACTIVE_NOT_RECRUITING
Genetic, Dietary and Environmental Influences on Vitamin D Metabolism	nan	COMPLETED
Environmental Influences on Vitamin D Status	nan	COMPLETED
Change in Free 25(OH)D After High Dose in Vitamin D Deficient Postmenopausal Women	nan	COMPLETED
The Influence of Food Matrix Delivery System on the Bioavailability of Vitamin D3	nan	COMPLETED
Immunolocalization of 1,25,Dihydroxyvitamin D3 in Aggressive Periodontitis Patients	nan	COMPLETED
Effects of Vitamin D Dose and Genotype of the Binding Protein in Infants and Children	nan	COMPLETED
Cholecalciferol for Vitamin D in Adult Cystic Fibrosis (CF) Patients	nan	COMPLETED
Getting Vitamin D Dosing Right	nan	COMPLETED
Gene Expression, Metabolomic, Microbiome, and Calcium Metabolism in Response to Varied Vitamin D Dosages	nan	COMPLETED
The Effect of Body Weight on Vitamin D Metabolism	nan	COMPLETED
Co-stimulatory Markers and Vitamin D Status in Anti-PD1 Treated Melanoma Patients	nan	COMPLETED
Prognostic Value of Vitamin D Levels in Egyptian Females With Breast Cancer	nan	UNKNOWN
The Impact of Selective Vitamin D Receptor Activation on Clinical Outcomes in Septic Patients	nan	NOT_YET_RECRUITING
Is There Association Between Vitamin D Levels And Insulin Resistance In Polycystic Ovary Syndrome?	nan	UNKNOWN
Serum 25-hydroxy Vitamin D [25(OH)D] Levels, Supplemental Vitamin D, and Parathyroid Hormone Levels in Premature Infants	nan	COMPLETED
Parathyroid Tumor Clonal Status	nan	RECRUITING
Vitamin D Status in Young Medical Residents	nan	COMPLETED
Vitamin D Supplementation in Older Women	nan	COMPLETED
Vitamin D and the Free Hormone Hypothesis	nan	COMPLETED
Non-inferiority RCT on Fish Waste-Derived vs. Synthetic Vitamin D Supplementation in Healthy Adults With Suboptimal Vitamin D Levels	nan	NOT_YET_RECRUITING

Related proteins — ESM-2 sequence neighbours (a GC binder may also engage these)

Protein	Name	Similarity
P02771	—	1.000	P02771 →
P28050	—	1.000	P28050 →
Q5XLE4	—	1.000	Q5XLE4 →
P53789	—	1.000	P53789 →
Q3MHN5	—	0.999	Q3MHN5 →
P21614	—	0.998	P21614 →
P04276	—	0.997	P04276 →
P14639	—	0.996	P14639 →
P02769	—	0.995	P02769 →
A6YF56	—	0.994	A6YF56 →
Q8MJ76	—	0.994	Q8MJ76 →
P02773	—	0.994	P02773 →
P43652	—	0.993	P43652 →
P49064	—	0.993	P49064 →
O35090	—	0.992	O35090 →
Q3T478	—	0.992	Q3T478 →
Q8MJU5	—	0.992	Q8MJU5 →
Q28789	—	0.992	Q28789 →
P49066	—	0.991	P49066 →
O89020	—	0.991	O89020 →
Q3SZ57	—	0.990	Q3SZ57 →
P19121	—	0.990	P19121 →
P49822	—	0.990	P49822 →
Q28522	—	0.989	Q28522 →
P08835	—	0.989	P08835 →
P84407	—	0.988	P84407 →
P35747	—	0.988	P35747 →
Q5NVH5	—	0.988	Q5NVH5 →
ALB	Albumin	0.988	landscape →
P21848	—	0.987	P21848 →