Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.39 |
| ▸ | GHSR | Q92847 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | TACR3 | P29371 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25342293 | 1.00 | TRPV6 (0.43) | TRPV6KDRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL9939266 | 0.75 | RORC (0.51) | NR1I2RORCKDM1AMAPK1CYP2D6 | |
| SCHEMBL29457450 | 0.74 | TRPV6 (0.47) | TRPV6KDRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL27211156 | 0.74 | TRPV6 (0.47) | TRPV6KDRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL25436571 | 0.74 | TRPV6 (0.47) | TRPV6KDRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL25436574 | 0.74 | TRPV6 (0.47) | TRPV6KDRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL30473722 | 0.74 | TRPV6 (0.47) | TRPV6KDRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL30801024 | 0.73 | SLC6A2 (0.42) | SLC6A2SLC6A4SLC6A3KDM1AMAOA | |
| SCHEMBL29180518 | 0.73 | SLC6A2 (0.42) | SLC6A2SLC6A4SLC6A3KDM1AMAOA | |
| SCHEMBL20798019 | 0.71 | CHRNB2 (0.42) | TRPV6KDRSIGMAR1GHSRCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116390917-A | MRGX2 antagonists | 葛兰素史密斯克莱知识产权发展有限公司 | 2023-07-04 | — | — | CN | disclosed |
| WO-2022073904-A1 | MRGX2 ANTAGONISTS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2022-04-14 | — | — | WO | disclosed |