SCHEMBL29458086

SCHEMBL29458086

O=CC=CN1CN(C=CC=O)CN(C=CC=O)C1

nearest known ligand 0.30

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 1/20 0.30
MAPK1 P28482 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL644462 0.78
SCHEMBL3541272 0.75 HSD17B10 (0.31)
SCHEMBL448720 0.75 HSD17B10 (0.31)
SCHEMBL644944 0.69 RECQL (0.48) MAPK1
SCHEMBL22440292 0.69 CA12 (0.30)
SCHEMBL22282962 0.69
SCHEMBL14582189 0.69 RECQL (0.48) MAPK1
SCHEMBL1164351 0.69 ALDH1A1 (0.32)
SCHEMBL2791591 0.68 RECQL (0.47) MAPK1
SCHEMBL8529790 0.67 ALDH1A1 (0.35)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4244235-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR TRANSFERRIN RECEPTOR 1 (TFR1) BicycleTX Limited (GB) 2023-09-20 EP claimed
EP-4003530-A1 HETEROTANDEM BICYCLIC PEPTIDE COMPLEXES BicycleTX Limited (GB) 2022-06-01 EP claimed
WO-2022101633-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR TRANSFERRIN RECEPTOR 1 (TfR1) BICYCLETX LIMITED (GB) 2022-05-19 WO claimed
WO-2025073871-A1 BICYCLIC PEPTIDE LIGAND COMPLEXES SPECIFIC FOR TFR1 BICYCLETX LIMITED (GB) 2025-04-10 WO disclosed
WO-2025046146-A1 POLYPEPTIDE SCREENING Bicycle TX Limited (GB) 2025-03-06 WO disclosed
WO-2024009108-A1 ANTI-INFECTIVE BICYCLIC PEPTIDE LIGANDS BICYCLETX LIMITED (GB) 2024-01-11 WO disclosed
US-11833211-B2 Methods of suppression and treatment of disease comprising administering bicycle peptide ligands specific for EphA2 BICYCLETX LIMITED (GB) 2023-12-05 US disclosed
EP-4274840-A1 ANTI-INFECTIVE BICYCLIC PEPTIDE LIGANDS BicycleTx Limited (GB) 2023-11-15 EP disclosed
EP-4274839-A1 ANTI-INFECTIVE BICYCLIC PEPTIDE LIGANDS BicycleTx Limited (GB) 2023-11-15 EP disclosed
EP-4274843-A1 ANTI-INFECTIVE BICYCLIC PEPTIDE LIGANDS BicycleTx Limited (GB) 2023-11-15 EP disclosed
US-20230144799-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR EphA2 BICYCLETX LIMITED (GB) 2023-05-11 US disclosed
EP-4153240-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR NECTIN-4 AND USES THEREOF BicycleTX Limited (GB) 2023-03-29 EP disclosed
EP-4065085-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR EPHA2 AND USES THEREOF BicycleTX Limited (GB) 2022-10-05 EP disclosed
WO-2022148970-A1 ANTI-INFECTIVE BICYCLIC PEPTIDE LIGANDS BICYCLETX LIMITED (GB) 2022-07-14 WO disclosed
WO-2022148968-A1 ANTI-INFECTIVE BICYCLIC PEPTIDE LIGANDS BICYCLETX LIMITED (GB) 2022-07-14 WO disclosed
WO-2022148971-A1 ANTI-INFECTIVE BICYCLIC PEPTIDE LIGANDS BICYCLETX LIMITED (GB) 2022-07-14 WO disclosed
EP-3965827-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR OX40 BicycleTX Limited (GB) 2022-03-16 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11833211-B2 Methods of suppression and treatment of disease comprising administering bicycle peptide ligands specific for EphA2 EPHA2, EPHB2, EPHB1 TRPA1 4681/4885MAPK1 2741/4885
US-20230144799-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR EphA2 EPHA2, EPHB2, ERBB2 TRPA1 4063/4885MAPK1 2407/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.