Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.49 |
| ▸ | CDC7 | O00311 | 2/20 | 0.47 |
| ▸ | HTR2A | P28223 | 4/20 | 0.41 |
| ▸ | HTR2C | P28335 | 4/20 | 0.41 |
| ▸ | HTR2B | P41595 | 4/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 5/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.37 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.37 |
| ▸ | PRNP | P04156 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.35 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.34 |
| ▸ | GMNN | O75496 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29458430 | 0.83 | PARP3 (0.43) | PARP3CDC7HTR2AHTR2CHTR2B | |
| SCHEMBL29458572 | 0.78 | CDC7 (0.46) | CDC7HTR2CCDK9PARP1PARP10 | |
| SCHEMBL11750196 | 0.77 | PARP3 (0.61) | PARP3HTR2AHTR2CHTR2BCA12 | |
| SCHEMBL6635520 | 0.77 | PARP3 (0.53) | PARP3CDC7HTR2AHTR2CHTR2B | |
| SCHEMBL12220005 | 0.77 | PARP3 (0.53) | PARP3CDC7HTR2AHTR2CHTR2B | |
| SCHEMBL13802926 | 0.76 | HTR2C (0.48) | CDC7HTR2AHTR2CHTR2BCDK9 | |
| SCHEMBL19131091 | 0.76 | CDC7 (0.47) | PARP3CDC7CDK9PARP1TNKS2 | |
| SCHEMBL12714442 | 0.74 | CDC7 (0.38) | PARP3CDC7HTR2AHTR2CHTR2B | |
| SCHEMBL1615464 | 0.74 | PRCP (0.38) | CDC7HTR2ACYP2D6PRCP | |
| SCHEMBL9880849 | 0.73 | S100A4 (0.40) | HTR2CPRNPPPARGNCOR2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220081422-A1 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | JANSSEN BIOTECH, INC. | 2022-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220081422-A1 | DIHYDROOROTATE DEHYDROGENASE INHIBITORS | DHODH, DLD, DPYD | PARP3 824/4885CDC7 1070/4885HTR2A 2563/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.