Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.56 |
| ▸ | GRM5 | P41594 | 2/20 | 0.47 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CKS1B | P61024 | 2/20 | 0.46 |
| ▸ | SKP1 | P63208 | 2/20 | 0.46 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 5/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20129625 | 0.87 | GPR119 (0.57) | GPR119GRM5GRM1HSD17B10ALDH1A1 | |
| SCHEMBL745368 | 0.82 | GPR119 (0.51) | GPR119GRM5GRM1CKS1BSKP1 | |
| SCHEMBL38664577 | 0.80 | CYP11B2 (0.45) | GPR119GRM1ALDH1A1CYP2D6CYP3A4 | |
| SCHEMBL484915 | 0.79 | HSD17B10 (0.65) | GPR119GRM1HSD17B10ALDH1A1CYP2D6 | |
| SCHEMBL30516861 | 0.79 | GPR119 (0.79) | GPR119HSD17B10ALDH1A1CYP2D6CYP3A4 | |
| SCHEMBL1459701 | 0.79 | GPR119 (0.79) | GPR119HSD17B10ALDH1A1CYP2D6CYP3A4 | |
| SCHEMBL29461446 | 0.78 | HSD17B10 (0.69) | GPR119HSD17B10ALDH1A1CYP2D6CYP3A4 | |
| SCHEMBL23108171 | 0.78 | GPR119 (0.52) | GPR119GRM5HSD17B10ALDH1A1CYP3A4 | |
| SCHEMBL29461422 | 0.78 | GPR119 (0.66) | GPR119HSD17B10ALDH1A1CYP2D6CYP3A4 | |
| SCHEMBL29461735 | 0.78 | HSD17B10 (0.76) | GPR119HSD17B10ALDH1A1CYP2D6CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114230569-A | Thiohydrazide compound, preparation method and application thereof | 深圳微芯生物科技股份有限公司 | 2022-03-25 | — | — | CN | disclosed |